期刊文献+

右美托咪啶在全麻拔管期中的应用 被引量:14

下载PDF
导出
摘要 目的探讨右美托咪啶在全麻拔管期中的应用效果。方法将全麻下行头颈部手术的60例患者随机分为观察组和对照组,各30例。于术毕前5 min停用麻醉维持药物,同时观察组缓慢静注右美托咪啶(0.5μg/kg),对照组给予等容量的生理盐水。分别记录麻醉前(T0)、拔管时(T1)、拔管后2 min(T2)、5 min(T3)、10 min(T4)时的平均动脉压(MAP)、心率(HR)、血氧饱和度(SpO2),术后1、6、12 h的视觉模拟评分(VAS)及拔管时患者是否出现躁动等情况。结果与T0比较,对照组MAP和HR于T1-3时升高(P〈0.05或P〈0.01),T4时逐渐恢复至麻醉前水平(P〉0.05);观察组MAP、HR及两组患者的SpO2于各时点无显著变化(P〉0.05)。观察组T1-3时的MAP、HR及术后1 h的VAS评分和躁动发生率均低于对照组(P〈0.05或P〈0.01)。结论右美托咪啶可减轻全麻拔管期患者的心血管反应,同时降低躁动发生率且有术后早期镇痛的作用。
出处 《山东医药》 CAS 北大核心 2011年第24期79-80,共2页 Shandong Medical Journal
  • 相关文献

参考文献6

  • 1石碧明,任永功,张雪萍,李亚丽,陶明哲,张中军.不同处理方法对全麻手术病人气管拔管应激反应的影响[J].中华麻醉学杂志,2005,25(7):501-504. 被引量:53
  • 2Gerlach AT, Murphy CV, Dasta JF. An updated focused review of dexmedetomidine in adults [J]. Ann Pharmaeother, 2009, 43 ( 12 ) : 2064 -2074.
  • 3Groeben H, Mitzner W, Brown RH. Effects of the alpha2-adrenoceptor agonist dexmedetomidine on bronchoconstriction in dogs [ J]. Anesthesiology, 2004,100 (2) :359-363.
  • 4Turan G, Ozgultekin A, Turan C, et al. Advantageous effects of dexmedetomidine on haemodynamic and recovery responses during extubation for intracranial surgery [ J ]. Eur J Anaesthesiol, 2008, 25(10) :816-820.
  • 5郝静,马正良.α2-受体激动剂在围术期中的应用进展[J].国际麻醉学与复苏杂志,2010,31(3):266-269. 被引量:97
  • 6Carollo DS, Nossaman BD, Ramadhyani U. Dexmedetomidine : a review of clinical applications [ J ]. Curr Opin Anaesthesiol, 2008, 21 (4) :457-461.

二级参考文献29

  • 1Hsu YW,Cortinez LI,Robertson KM,et al.Dexmedetomidine pharmacodynamics:Part I:crossover compaison of the respiratory effects of dexmedetomidine and remifentanil in healthy volunteers.Anesthesiology,2004,101(5):1066-1076.
  • 2Rozet I.Anesthesia for functional neurosurgery:the role of dexmedetomidine.Curr Opin Anaesthesiol,2008,21(5):537-543.
  • 3Uyar AS,Yagmurdur H,Fidan Y,et al.Dexmedetomidine attenuates the hemodynamic and neuroendocrinal responses to skull-pin head-holder application during craniotomy.J Neurosurg Anesthesiol,2008,20(3):174-179.
  • 4Schmidt AP,Valinetti EA,Bandeira D,et al.Effects of preanesthetic administration of midazolam,clonidine,or dexmedetomidine on postoperative pain and anxiety in children.Paediatr Anaesth,2007,17(7):667-674.
  • 5Chu KS,Wang FT,Hsu HT,et al.The effectiveness of dexmedetomidine infusion for sedating oral cancer patients undergoing awake fibreoptic nasal intubation.Eur J Anaesthesiol,2010,27(1):36-40.
  • 6Ayoglu H,Yapakci O,Ugur MB,et al.Effectiveness of dexmedetomidine in reducing bleeding during septoplasty and tympanoplasty operations.J Clin Anesth,2008,20(6):437441.
  • 7Tufanogullari B,White PF,Peixoto MP,et al.Dexmedetomidine infusion during laparoscopic bariatric surgery:the effect on recovery outcome variables.Anesth Analg,2008,106(6):1741-1748.
  • 8Ohtani N,Kida K,Shoji K,et al.Recovery profiles from dexmedetomidine as a general anesthetic adjuvant in patients undergoing lower abdominal surgery.Anesth Analg,2008,107(6):1871-1874.
  • 9Bekker AY,Kaufman B,Samir H,et al.The use of dexmedetomidine infusion for awake craniotomy.Anesth Analg,2001,92(5):1251-1253.
  • 10Huncke T,Chan J,Doyle W,et al.The use of continuous positive airway pressure during an awake craniotomy in a patient with obstructive sleep apnea.J Clin Anesth,2008,20(4):297-299.

共引文献147

同被引文献119

  • 1李民,张利萍,吴新民.右美托咪啶在临床麻醉中应用的研究进展[J].中国临床药理学杂志,2007,23(6):466-470. 被引量:483
  • 2马朋林,赵金柱,苏瑾文,李秦,王宇.脑电双频指数与镇静-躁动评分评价机械通气患者镇静程度可靠性的比较研究[J].中国危重病急救医学,2006,18(6):323-326. 被引量:36
  • 3Ohtani N,Kida K,Shoji K,et al.Recovery profiles fromdexmedetomidinne as a general anesthetic adjuvant in patientsundergoing lower abdominal surgery[J].Anesth Analg,2008,107(6):1871-1874.
  • 4陈杰,王珊娟.麻醉前用药的药理.见:杭燕南,庄心良,蒋豪,等主编.当代麻醉学.上海:上海科学技术出版社,2002.213.
  • 5吴新民,许幸,王俊科,王鲲鹏,薛张纲,缪长虹,邓小明,艾登斌,于浩.静脉注射右美托咪啶辅助全身麻醉的有效性和安全性[J].中华麻醉学杂志,2007,27(9):773-776. 被引量:242
  • 6Turan G,Ozgultekin A,Turan C,et al.Advantageous effects of dexmedetomidine on hemodynmaic and recovery responses during extubation for intractranial surgery[J].Eur J Anaesthesiol,2008,25(10) :816-820.
  • 7Kuzucuo GT,Bol ukba sloglu I,Arslan G.Comparison of the activity and reliability of intravenous administration of midazolam and dexmedetomidine on sedation levels under epidural[J].Anesthesia,2010,22(3) :121.
  • 8Elvan EG,Oc B,Uzun S,et al.Dexmedetomidine and postoperative shivering in patients undergoing elective abdominal Elvan EG Oc B Uzun hysterectomy[J].Eur J Anaesthesiol,2008,25 (5):357-364.
  • 9Massad IM,Mohsen WA,Basha AS,et al.A balanced anethesia with dexmedetomidine decreeases postoperative nauses and vomiting after laparoscopic surgery[J].Clin Anesth,2009,21(7):493-501.
  • 10Hsu YW,Cortinez LI,Robertson KM,et al.Dexmedetomidine phramacodynamics:part I.Crossover comparison of the respiratory effects of dexmedetomidine and remifentanil in healthy volunteers[J].Anesthesiology,2004,101(5):1066-1076.

引证文献14

二级引证文献56

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部