Snail蛋白在骨肉瘤中的表达及临床意义

Expression of Snail Protein in Patients with Osteosarcoma and Its Clinical Significance

目的观察Snail蛋白在骨肉瘤中的表达,探讨其在骨肉瘤发生、发展中的作用。方法采用免疫组化SP法检测骨肉瘤组织42例、骨软骨瘤10例中Snail蛋白的表达。结果①Snail蛋白在骨肉瘤中表达高于骨软骨瘤组织中的表达,差异有统计学意义(P<0.01);②Snail蛋白在骨肉瘤组织中的表达与软组织浸润、Enneking分期、肺转移密切相关(P<0.01),而与性别、年龄、肿瘤部位、Dahlin类型无关(P>0.05);③骨肉瘤中Snail蛋白阳性患者累积生存率明显低于阴性患者,差异有统计学意义(P<0.01)。结论 Snail蛋白在骨肉瘤组织中的高表达提示其对骨肉瘤的发生、发展和浸润、转移起重要作用并预示预后不良。

Objective To observe the expression of Snail protein in osteosarcoma tissues,and to explore its roles in the development and progression of the disease.Methods Immunohistochemical assay（SP method） was used to detect the expressions of Snail in 42 osteosarcoma tissues and 10 osteochondroma tissues.Results ①Expression rate of Snail protein in osteosarcoma tissues was higher than that in osteochondroma tissues,and the differences were significant（P0.01）.②Expression of Snail protein in osteosarcoma were closely related with soft tissue involvement,Enneking stage,and lung metastases（P0.01）,but not related with gender,age,mass site and Dahlin types（P0.05）.③The survival rate of osteosarcoma patients with Snail protein was significant lower than that in osteosarcoma patients without Snail protein,and the difference was significant（P0.01）.Conclusion The overexpression of Snail in Osteosarcoma tissues indicates that it plays an important role in development and progression of osteosarcoma and predicts poor prognosis.