摘要
目的 研究正常家猪对32P玻璃微球(32PGMS)肝动脉内栓塞后内放射性的急性和亚急性毒性反应,探讨32PGMS的临床应用安全性和使用安全剂量范围。方法 10 只正常家猪分为两组,实验组5 只,对照组5 只。分别用直径46 ~76 μm 的32PGMS和31PGMS作肝动脉栓塞。术后行血常规、肝肾功能等实验室检查,同时,行肝区和其他器官放射剂量分布等监测。术后1 、2、4、8 、16 周分别处死猪,行光学显微镜( 简称光镜) 和电子显微镜(简称电镜)检查。结果 32PGMS均匀分布于给药动脉营养的全肝或肝叶内,达汇管区肝最小动脉水平,实验室及病理均显示肝组织有轻微的损伤,但均为一过性,约在8 周左右恢复正常。肝组织损伤的超微结构改变以1~2 周内最明显。实验组所接受的32PGMS宏观平均吸收剂量为48~190 Gy。结论 用32PGMS行肝动脉栓塞为一有效、安全、可行的方法。
Objective To evaluatethe acuteand sub acutetoxicresponsetotranscatheterhepatic arterial emolization of Phosphorus 32 glass microspheres (32P GMS) in pigs- Methods Selective transcatheter hepatic arterialembolization was performedin10 healthy domestic pigsusing 46 -76 μm 32P GMS(5 pigs,48- 190 Gy) and nonradioactiveglass microspheres(5 pigs) ascontrolgroup- Bloodtestsincludingcomplete bloodcount,liver and kidneyfunctiontestswere measured- The distribution of32Pwas monitored- The pigs weresacrificedat1 ,2 ,4, 8 and16 weeks,respectively- Microscopicand ultrastructuralhistopathologyoftheliverand kidney wasevaluated- Results 32 P GMS was distributed evenly over the liver purfused- The GMS were located in the hepatic micrioarteriesandfew collateralfeeding arteries wereformed- Transientelevation oftransaminases wasobservedin allpigs following 32P GMSadministration- No evidence of myelosuppression was found- Swelling and vacuolar degeneration ofhepatocytesandlymphocyteinfiltrationintheliver were demonstratedinthe pigsinjected with 32P GMS- However,no hepatic parenchymal necrosis occurred- Conclusions This study suggests thatintraarterial hepatic administration of32P GMSwith doselessthan190 Gyis welltolerated-
出处
《中华放射学杂志》
CAS
CSCD
北大核心
1999年第10期667-671,共5页
Chinese Journal of Radiology
基金
江苏省科委资助
关键词
肝癌
肝动脉
栓塞疗法
磷32玻璃微球
肝组织损伤
Phosphorusradioisotopes Microspheres Animals,laboratory Hepatic artery Embolization,therapeutic