一个中国人群哮喘与5号染色体的连锁分析

Linkage analysis of chromosome 5 and asthma in a Chinese population

目的 探讨哮喘与５ｑ３１３３ 的连锁关系。方法 采用 Ｌｏｄ ｓｃｏｒｅ 分析方法对一个中国人群哮喘与５ 号染色体上的几个微卫星标记的连锁关系进行了研究。结果 哮喘与５ｑ３１３３ 之间不存在连锁。结论 ５ｑ３１３３ 区域的基因可能不对中国这一人群哮喘的遗传起主要作用。

Objective To investigate the linkage between asthma and 5q31 33 in a Chinese population.Methods The linkage between microsatellite markers in 5q and asthma and allergy was tested by lod score analysis.Results The linkage between asthma and 5q31 33 was not confirmed.Conclusion The genes at 5q31 33 are not likely to contribute to inheritance of asthma in this Chinese population.