永久性肺毛玻璃样结节的CT与组织病理学比较

Comparison of thin-section CT expression and histopathology of persistent pulmonary nodular ground-glass opacity

为了结合组织病理学回顾性分析薄层CT下肺毛玻璃样结节(GGO)的特征,分析49例(53个结节)永久性肺毛玻璃样结节(GGO)患者的临床资料。CT扫描包括结节大小、形状、外形和内部特征。采用Kruskal-Wallis检验和Fisher检验分析结果。49例患者中32例共40个GGO(75.47%)为细支气管肺泡细胞癌(BAC)或以BAC为主要成分的腺癌,3个GGO(5.67%)为非典型腺瘤性增生,10个(18.87%)为非特异性肺纤维化。这3种疾病的薄层CT表现差异无统计学意义,P>0.05。大约75.47%的GGO为细支气管肺泡细胞癌(BAC)或以BAC为主要成分的腺癌,在薄层CT上的表现与其他类型的GGO没有明显形态学差异。

The Objective of this study was to retrospectively compare pure pulmonary ground-glass opacity （GGO） nodules observed on thin-section CT images with histopathologie findings. Histopathologic specimens were obtained from 53 GGO nodules in 49 patients. CT scans were assessed in terms of nodule size, shape, contour,internal characteristics. Differences in thin-section CT findings according to histopathologic diagnoses were analyzed by Kruskal-Wallis test and Fisher exact test. Of 53 nodules in 49 patients, 40（75.47%） proved to be broncholoalveolar cell carcinoma （BAC） or adenocarcinoma with predominant BAC component, three （5.67 %） atypical adenomatous hyperplasia, and 10 （18.87%） nonspecific fibrosis or organizing pneumonia. No significant differences in morphologic findings on thin-section CT scans were found among the three diseases （P〉0.05）. In conclusion, about 75.47 % of persistent pulmonary GGO nodules are attributed to BAC or adenocarcinoma with predominant BAC component, and at thin-section CT, these nodules do not manifest morphologic features that distinguish them from other GGO nodules with different histopathologic diagnoses.