期刊文献+

肝脏疾病对腹膜透析患者血氨水平的影响 被引量:1

The effect of suffered from liver diseases on venous ammonia in continuous ambulatory peritoneal dialysis patients
下载PDF
导出
摘要 目的:探讨同时伴有肝脏疾病的持续性非卧床腹膜透析(CAPD)患者对体内血氨水平的影响。方法:对2010年3月在北京大学附属第三医院肾内科接受CAPD患者进行横断面调查。采用全自动干式生化分析仪测定静脉血氨;同时收集相关的生化指标。采用均数比较及多因素分析等统计学方法探讨CAPD患者肝脏疾病与血氨升高之间的关系。结果:共144例符合条件的患者入选本研究。根据总体有无肝脏疾病将患者分为两组,结果为男性患肝脏疾病者明显多于女性(P<0.05),前者血白蛋白(ALb)和平方根残肾K t/V(P<0.05)均明显小于后者,而前者血氨(P<0.01)明显大于后者。多元线性回归分析提示,高的PNA、血白蛋白减少、低的平方根残肾K t/V及有肝脏疾病是静脉血氨升高的独立影响因素(R2=0.339,P<0.05)。结论:本研究表明在肾脏功能衰竭的CAPD的患者中,当同时患有肝脏疾病时,更容易造成患者血氨升高。 Objective: To study the effect of suffered from liver diseases on venous ammonia in patients undergoing continuous ambulatory peritoneal dialysis(CAPD).Methods: A cross-sectional study was performed in CAPD patients treated in the division of nephrology Peking University Third Hospital in March 2010.We collected data including venous ammonia,OH,residual renal function,dialysis adequacy and other biochemical indicators.Comparisons between groups and multivariate analysis were used to explore the relationship between the liver diseases and venous ammonia.Results: 144 patients were included in the present study.Patients were divided into two groups according to with or without liver disease.Venous ammonia,gender,ALb,and residual renal function were significantly different in the two groups.Multivariate analysis further showed that PNA,ALb,residual renal function,and had liver diseases were independent risk factors affecting the level of venous ammonia after adjusting for gender,age,OH,BUN,dialysis adequacy,lgCRP and urine volume(R^2=0.339,P0.05).Conclusion: This study showed that liver diseases effected upon the elevated blood ammonia in CAPD patients.
出处 《河南医学研究》 CAS 2011年第2期161-164,共4页 Henan Medical Research
关键词 血氨 肝脏疾病 残余肾功能 持续性非卧床腹膜透析 serum ammonia liver diseases residual renal function CAPD
  • 相关文献

参考文献17

  • 1Gundling F, Seidl H, Schmidt T, et al. Blood ammonia level in liver cirrhosis: a condition sine qua non to confirm hepatic encephalopathy [ J ]. Eur J Gastroenterol Hepatol,2008,20 ( 3 ) :246-247.
  • 2Ookawara S,Suzuki M,Saitou M. Acute encephalopathy due to thiamine deficiency with hyperammonemia in a chronic hemodialysis patient: a case report[ J ]. Nippon Jinzo Gakkai Shi,2003,45 (4) :393- 397.
  • 3Bezinover D, Douthitt L, McQuilan PM, et al. Fatal hyperammonemia After Renal Transplant due to Late-Onset Urea Cycle Deficiency: A Case Report [ J ]. Transplantation Proceedings, 2010, 42 ( 1 ) : 1982-1985.
  • 4Paralso V, Francos M, Rodriguez-Berzosa F, et al. Portosystemie encephalopathy in a patient treated with peritoneal dialysis [ J ]. Am J Kidney Dis. 2007,49(6) :854-858.
  • 5Bargman JM, Bick J, Cartier P, et al. Guidelines for adequacy and nutrition in peritoneal dialysis. Canadian Society of Nephrology[ J]. J Am Soc Nephrol, 1999,10 ( 13 ) :311-321.
  • 6Nolph KD, Moore HL, Prowant B, et al. Cross sectional assessment of weekly urea and creatinine clearances and indices of nutrition in continuous ambulatory peritoneal dialysis patients[ J ]. Perit Dial Int, 1993,13 (3) : 178-183.
  • 7Arbeiter AK, Kranz B, Wingen AM, et al. Continuous venovenous haemodialysis (CVVHD) and continuous peritoneal dialysis (CPD) in the acute management of 21 children with inborn errors of metabolism[J]. Nephrol Dial Transplant. 2010,25 (4) :1257-1265.
  • 8Oshiro S, Kochinda T, Tana T, et al. A patient with adult-onset type II citrullinemia on long-term hemodialysis: reversal of clinical symptoms and brain MRI findings[ J]. Am J Kidney Dis,2002, 39 ( 1 ) : 189-192.
  • 9Clemmesen JO, Larsen FS, Kondrup J, et al. Cerebral herniation in patients with acute liver failure is correlated with arterial ammonia concentration [ J ]. Hepatology, 1999 ;29 ( 3 ) :648-653.
  • 10Wright G, Noiret L, Damink SW, et al. Interorgan ammonia metabolismin liver failure: the basis of current and future therapies [J]. Liver Int. 2011,31 (2) :163-175.

二级参考文献1

共引文献85

同被引文献5

引证文献1

二级引证文献1

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部