期刊文献+

EGCG抗癌靶点中酪氨酸激酶受体RTKs的研究进展 被引量:2

下载PDF
导出
摘要 茶作为癌症化学预防物的研究已经经历了20多年,其抑制癌发生发展的机制主要归结于茶多酚结构。而茶主要多酚成分表没食子儿茶素没食子酸酯(epigallocatechin-3-gallate,EGCG)被认为最具生物活性,因此,对其研究最为透彻。
出处 《同济大学学报(医学版)》 CAS 2011年第3期116-119,共4页 Journal of Tongji University(Medical Science)
基金 国家自然科学基金(30840031:30970726)
  • 相关文献

参考文献20

  • 1Hubbard SR,Mohammadi M,Schlessinger J.Auto regulatory mechanisms in protein-tyrosine kinases[J].J Biol Chem,1998,273:11987-11990.
  • 2Mark AL,Joseph S.Cell signaling by receptor tyrosineinases[J].Cell,2010,147 (7):1117-1134.
  • 3Ezwick JB,Ullrich A.Receptor tyrosine kinase signalling as a target for cancer intervention strate-gies[J].Endocrine-Related Cancer,2001,8:161-173.
  • 4Kolibaba KS,Druker BJ.Protein tyrosine kinases and cancer[J].Biochim Biophys Acta,1997,13339 (3):F217 -248.
  • 5Hiromasa Y,Shinichi T,Tetsuya M.Impact of EGFR mutation analysis in non-small cell lung cancer[J].Lung Cancer,2009,63:315-321.
  • 6Nicholson RI,Gee JM,Harper ME.EGFR and cancer prognosis[J].Eur J Cancer,2001,37(Suppl):S9.
  • 7Mikkel WP,Vadim T,Nina P,et al.Expression of a naturally occurring constitu-tively active variant of the epidermal growth factor receptor in mouse fibroblasts increases motility[J].Int J Cancer,2004,108:643 -653.
  • 8Michael VG,Roza Z,Mikkel WP,et al.EGFR escapes down-regulation due to impaired interna-lization and sorting to lysosomes[J].Carcinogenesis,2007,28(7):1408-1417.
  • 9Yoshihisa U,Yasuyo O,Yoshiatsu S,et al.Coexpression of epidermal growth factor receptor and transforming growth factor-a predicts worse prognosis in breast-cancer patients[J].Int J Cancer,2000,89:484-487.
  • 10Garrett TP,McKem NM,Lou M,et al.The crystal structure of a truncated ErbB2 ectodomain reveals an active conformation,poised to interact with other ErbB receptors[J].Mol Cell,2003,11 (2):495 -505.

同被引文献22

  • 1李士坤,陈克河,任庆梅.槲皮素对人食管癌Eca-109细胞的分化诱导作用[J].中国实用医药,2007,2(36):14-15. 被引量:2
  • 2向廷秀,陶小红,姜政,王丕龙,谯敏.槲皮素对SGC-7901胃癌细胞生长及HSP70和EGFR表达的影响[J].西安交通大学学报(医学版),2007,28(4):411-414. 被引量:12
  • 3Yang CS, Wang X, Lu G, et al. Cancer prevention by tea: animal studies, molecular mechanisms and human relevance[J]. Nat Rev Cancer,2009,9(6):429-439.
  • 4Tachibana H, Koga K, Fujimura Y, et al. A receptor for green tea polyphenol EGCG [J]. Nat Struct Mol Biol, 2004,11(4):380-381.
  • 5Margaritescu C, Pirici D, Simionescu C, et al. VEGF and VEGFRs expression in oral squamous cell carcinoma[J]. Rom J Morphol Embryol, 2009, 50(4):527-548.
  • 6Narotzki B, Reznick AZ, Aizenbud D, et al. Green tea: a promising natural product in oral health [J]. Arch Oral Biol, 2012, 57(5):429-435.
  • 7Singh BN, Shankar S, Srivastava RK. Green tea eatechin, epigallocatechin-3-gallate(EGCG): mechanisms, perspec- tives and clinical applications [J]. Bioehem Pharmaeol, 2011, 82(12):1807-1821.
  • 8Hynes NE, Lane HA. ERBB receptors and cancer: the complexity of targeted inhibitors [J]. Nat Rev Cancer, 2005,5(5):341-354.
  • 9Uehara M, Sano K, Ikeda H, et al. Expression of vascular endothelial growth factor and prognosis of oral squamous cell carcinoma[J]. Oral 0ncol,2004,40(3):321-325.
  • 10袁江兰,刘晖,康旭,邹国林.表皮生长因子受体酪氨酸激酶结构域与其抑制剂染料木素的模拟对接[J].生物工程学报,2008,24(10):1813-1817. 被引量:4

引证文献2

二级引证文献14

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部