摘要
建立一种双抗夹心酶免法测定46例糖尿病患者血清Ⅳ型胶原（cⅣ）含量。结果表明，糖尿病患者血清cⅣ含量显著高于正常对照组（P＜0．01），且随病程加长cⅣ水平逐渐升高。尿蛋白阳性的糖尿病患者血清cⅣ含量显著高于尿蛋白阴性组。研究提示血清cⅣ可作为监测糖尿病并发症指标。
An enzyme-linked Immunoassay(ELISA) for type Ⅳ collagen (c Ⅳ) with monoclonal antibody was developed. Serum c Ⅳ levels measured in 46 Diabetic patients were significently higher (P<0. 01) than in 56 healthy subjects, and were increased with the incidence of Diabetic complications. These results implied that serum c Ⅳ levels seem to be a useful, non-invasive marker for assessment of the activity of diabetic microan-giopathy.
出处
《陕西医学检验》
1999年第4期13-14,共2页
Shaanxi Journal of Medical Laboratory Sciences
