脑室内血肿对丘脑背侧神经元的毒性损伤

The toxic damage of intraventricular hematoma to thalamic dorsal neurons

目的： 探讨脑室内血肿对丘脑背侧神经元是否具有毒性损伤作用。方法： 在鼠脑室内注血后６ 小时， 观察丘脑背侧神经元的病理组织学改变， 检测丘脑背侧组织ＡＴＰ酶活性及Ｎａ＋ 、Ｋ＋ 、Ｃａ２＋ 含量。结果： 脑室内注血后６ 小时， 丘脑背侧神经元虽未见明显坏死， 但胞内结构已开始发生变化， Ｎａ＋ － Ｋ＋ － ＡＴＰ酶、Ｃａ２＋ － ＡＴＰ酶活性明显降低， Ｎａ＋ 、Ｃａ２＋ 含量则明显增高。结论： 脑室内血肿对丘脑背侧神经元具有毒性损伤作用。

Objective:To investigate whether the thalamic dorsal neurons suffer toxic damage from intraventricular hematoma.Methods: Six hours after blood was injected into ventricle of rats,tissue ATP ase activity,contents of Na +,K +,Ca 2+ and histopathological changes in the dorsal region of thalamus were measured.Results:Although neuron necrosis had not been found,the change of construction inside the neurons had occured. Meanwhile,tissue ATPase activity decreased significantly and Na +,Ca 2+ contents increased remarkably.Conclusion:The thalamic dorsal neurons suffer toxic damage from hematoma itself following intraventricular hemorrhage.$$$$