电化学和电化学发光核酸适体传感器

Electrochemical and Electrochemiluminescent Aptasensors

核酸适体具有亲合力强、选择性高、稳定性好、易于修饰等优点,广泛用于对目标物如蛋白质、小分子等的灵敏检测。电化学具有成本低、灵敏度高、仪器小巧等优点。近年来,构建基于核酸适体的电化学传感器,已经成为一个热门的研究领域。本文重点评述了2005年以来核酸适体的电化学传感器的研究进展,并展望其发展前景。

Aptamers have been widely used for the detection of target molecules owing to their chemical stability,easy modification and remarkable specificity and affinity with various target molecules.Electrochemical methods are well known for low cost,high sensitivity and miniature instruments.Recently,the design of electrochemical aptasensors has attracted remarkable attention in the field of biosensors.This paper mainly reviewed the developments of this field since 2005,and the prospects are discussed.