替罗非班在急诊介入治疗急性心肌梗死患者中的应用

The application of tirofiban to emergency intervention therapy in paitent with acute myocardial infarction

目的观察替罗非班对行急诊介入治疗的急性心肌梗死患者的有效性和安全性。方法将住院行急诊经皮冠状动脉介入治疗的急性心肌梗死患者113例随机分为替罗非班组53例和对照组60例。比较2组介入治疗情况、短期主要心脏不良事件(MACE)发生率和安全性。结果替罗非班组患者术后心肌梗死溶栓(TIMI)血流≤2级比例明显低于对照组,3级比例明显高于对照组,差异均有统计学意义(P<0.05)。2组患者术后出血及血小板减少情况比较,差异均无统计学意义(P>0.05)。替罗非班组患者短期MACE的发生率为11.3%显著低于对照组的26.7%,差异有统计学意义(P<0.05)。结论替罗非班在急性心肌梗死的急诊介入治疗过程中是有效的和安全的。

Objective To observe the efficacy and safety of tirofiban to emergency intervention therapy in paitent with acute myocardial infarction.Methods 113 cases patients with acute myocardial infarction who were given emergency percutaneous coronary intervention were randomly to tirofiban group（53 cases） and control group（60 cases）.Compared intervention condition,the rate of short-term major adverse cardiac events（MACE） and safety of two geoups.Results The ratio of TIMI flow≤2 level of tirofiban group was significantly lower than that of control group,the ratio of 3 level was significantly higher than that of control group,the difference were statistically significant（P〈0.05）.Compared to the situation of postoperative bleeding and thrombocytopenia of two groups,the difference were not statistically significant（P〉0.05）.The incidence rate of MACE of tirofiban group（11.3%） was significantly lower than that of control group（26.7%）,the difference was statistically significant（P〈0.05）.Conclusion Tirofiban to emergency intervention therapy in paitent with acute myocardial infarction is effective and safe.