摘要
目的探讨耐碳青霉烯类铜绿假单胞菌(PAE)及鲍氏不动杆菌(ABA)的临床分布与耐药特性,为临床抗感染治疗和合理使用抗菌药物提供依据。方法采用微量肉汤稀释法测定12种抗菌药物的最低抑菌浓度(MIC)。结果两年共分离耐碳青霉烯类PAE和ABA分别为261、117株,两者>80.0%来源于呼吸道标本,41.0%耐碳青霉烯类PAE和64.9%耐碳青霉烯类ABA来自于重症监护病房,耐碳霉烯类ABA的多药耐药性比PAE更为严重,该菌株除头孢哌酮/舒巴坦耐药率在23.1%外,其他均>70.0%,亚胺培南和美罗培南耐药率分别为93.1%和96.6%,而耐碳青霉烯类PAE对亚胺培南和美罗培南耐药性却差异较大,16.0%菌株对亚胺培南耐药,而对美罗培南敏感,其中可能存在不同的耐药机制。结论耐碳青霉烯类PAE和ABA的耐药率在不断上升,特别是多药耐药和泛耐药株的增多,因此应慎重、合理地使用碳青霉烯类抗菌药物,密切关注PAE和ABA耐药的发展,采取有效的感染控制措施。
OBJECTIVE To investigate clinical characteristics of distribution and drug resistance of carbapenem- resistant Psedomonas aeruginosa and Acinetobacter baumannii. METHODS Broth microdilution method was employed to determine the minimum inhibitory concentration （MIC） of 261 isolated carbapenem-resistant P. aeruginosa and 117 isolated A. baumannii. RESULTS Separation of two years, carbapenem-resistant P. aerugi- nosa and A. baumannii, respectively 261, 117, both more than 80.0% from respiratory tract specimens. 41.0% of the carbapenem-resistant P. aeruginosa 64.9% of carbapenem-resistant A. baumannii were isolated from the intensive care ward. Carbapenem-resistant A. baumannii in multi-drug resistance than the carbapenem-resistant P. aeruginosa was more seriously, this strain except cefoperazone/sulbactam resistance rates of 23.1 %, while the rest were above 70. 0%, imipenem and meropenem resistance rates were 93. 1% and 96. 6%. Carbapenemresistant P. aeruginosa resistant to imipenem and meropenem situation is quite different, 16 % of strains resistant to imipenem, while meropenem-sensitive, which may have different mechanisms of drug resistance. CONCLUSION Carhapenem-resistant P. aeruginosa and A. baumannii resistance rates on the rise, especially in multi-drug resistance and pan-resistant strains has increased. So be careful, rational use of carbapenem antibacterial drugs, pay close attention to P. aeruginosa and A. baumannii resistant to the development of effective infection control measures.
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2011年第13期2813-2815,共3页
Chinese Journal of Nosocomiology
