743例患者医院感染鲍氏不动杆菌的分布及耐药性分析

Distribution of acinetobacter baumanii causing nosocomial infections in 743 patients and drug resistance

目的了解医院感染鲍氏不动杆菌分布及对多种抗菌药物的耐药性,为临床治疗医院获得性鲍氏不动杆菌感染提供参考。方法对1998年1月-2007年12月由鲍氏不动杆菌引起的医院感染进行回顾性统计分析。结果共分离出鲍氏不动杆菌743株,标本来源以痰、创口分泌物和血液为主,分别占68.5%、15.3%及4.7%;医院感染主要发生在ICU、神经外科,各占24.9%及11.8%;鲍氏不动杆菌对头孢哌酮/舒巴坦、亚胺培南的总耐药率为20.6%和7.9%,阿米卡星、环丙沙星、哌拉西林/他唑巴坦、替卡西林/克拉维酸、哌拉西林的总耐药率分别为53.0%、59.2%、59.8%、65.1%、65.1%。结论鲍氏不动杆菌引起的医院感染非常严重,应加强对鲍氏不动杆菌引起的医院感染耐药性监测,合理应用抗菌药物。

OBJECTIVE To investigate the distribution of nosocomial Acinetobacter baumanii （ABA） infection and its drug resistance. METHODS A retrospective analysis for nosocomial A. baumanii infection was made from Jan 1998 to Dec 2007. RESULTS A total of 743 strains were isolated from various specimens during the ten years specimens. The most ABA strains were cultured from the infection of sputum and wounds. Nosocomial infection caused by ABA happened mainly in intensive care units （ICU） （24.9 %） and department of cadre （11.8%）. The resistant rates of ABA to cefoperazone/sulbacta, amikacin, imipenem, ciprofloxacin, ceftazidime, cefepime, piperacillin,tazobactam, ticacillin/clavulanic acid, piperacillin and aztreonam were 20. 6%, 7. 9%, 53. 0%, 59.2%, 59.8%, 65. 1% and 65. 1% , respectively. CONCLUSION Nosocomial infections caused by ABA is serious. It is important to monitor drug resistance of nosocomial ABA infection and to use Antimicrobial agents rationally.