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群体感应与细菌毒力 被引量:4

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摘要 细菌产生自诱导物质(autoinducers,AIs)作为细菌间相互联系的信号分子,其浓度随着细菌的增殖而升高。由于该信号分子能自由通过细胞膜,因此细胞内外的浓度相近。当该信号分子浓度达到一定浓度,就激活细菌胞内的受体,从而改变基因表达,这种现象就是群体感应(quorumsensing,Qs)。研究最多的Qs信号分子是革兰阴性菌N-酰基高丝氨酸内酯(N—acylhomoserinelactones,AHLs)和革兰阳性菌自诱导多肽(auto~inducingpolypeptides,AIP),
出处 《中华医院感染学杂志》 CAS CSCD 北大核心 2011年第13期2866-2870,共5页 Chinese Journal of Nosocomiology
基金 国家自然科学基金(81071408)
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