氯沙坦与苯那普利单独和联合治疗高血压对血管紧张素Ⅱ的影响

Effects of Losartan or Combined with Benazepril on the BP and \;AngiotensinⅡ in Hypertension

目的：评价氯沙坦治疗高血压病的有效性和安全性及其对ＡｎｇⅡ的影响。方法：９０ 例高血压病患者， ３０ 例接受氯沙坦（ＬＯＳ）治疗， ３０例接受苯那普利（Ｂｅｎ）治疗，３０ 例接受氯沙坦与苯那普利联合（Ｃｏｍ ）治疗，均为口服片剂，对照观察６ 周。结果：Ｌｏｓ与Ｂｅｎ 组总有效率分别为９０％ 、８６．６％ ，Ｃｏｍ 组总有效率为９６．６％ ， 优于Ｌｏｓ组和Ｂｅｎ 组， 但差异无显著性（Ｐ＞ ０．０５）。氯沙坦使ＡｎｇⅡ增高， 苯那普利使ＡｎｇⅡ下降， 分别与治疗前对照均有显著差异（Ｐ＜ ０．０１）。不良反应发生率Ｌｏｓ组为１２．５％ ， Ｂｅｎ 组为２３．３％ ，Ｃｏｍ 组为１３．３％ 。Ｂｅｎ 组与Ｌｏｓ组和Ｃｏｍ 组分别对照均有显著差异（Ｐ＜ ０．０１）。结论： 氯沙坦治疗高血压病安全有效，耐受性良好。

Aim: To evaluate the effects and safety of losartan on the blood pressure,left ventricular remodeling and angiotensin Ⅱ in treatment of essential hypertension. Methods: 90 patients were randomly divided into three groups: 30 patients treated with losartan (50～100 mg qd), 30 patients treated with benazepril(10 mg qd), 30 patients treated with combination of losartan and benazepril(50 mg qd and 5 mg qd), all groups were treated for 6 weeks. Results: According to office blood pressure or ambulatory blood pressure measurment the overall efficacy rate of losartan and benazepril was 90% and 86.6% respectively, and combination group was 96.6%. No statistical singnificant difference among the three groups was found( P >0.05). Losartan caused increases in serum angiotensinⅡ; benazepril caused decreases in serum angiotensin Ⅱ( P<0.01 vs before treatment).The adverse reaction rate of losartan and benazepril was 12.5% and 23.3% respectively, and the combination group was 13.3%. Benazepril group seems to have higher adverse drug reaction rate( P <0.01). Conclusion:Losartan is effective and safe in treatment of hypertension.