科素亚对高血压病患者胰岛素抵抗的影响

Effects of Cozaar on Insulin Resistance in Patients with Essential \;Hypertension

目的：探讨科素亚对高血压病患者胰岛素抵抗的关系。方法：选２５ 例高血压病患者取空服静脉血测定血脂、血尿酸、血浆肾素、血管紧张素Ⅱ，并行口服葡萄糖耐量试验，测血糖及血浆胰岛素， 之后服用科素亚５０～１００ ｍ ｇ／ｄ，共４ 周，于第４ 周重复上述检查及葡萄糖耐量试验，并用血糖、血浆胰岛素来计算空腹血浆胰岛素与血糖比值（Ｉ／Ｇ）、糖耐量曲线下面积（ＡＶＣＢＧ）、胰岛素释放曲线下面积（ＡＶＣＩＳ）来比较治疗前后有无显著差异。结果：科素亚治疗后高血压病患者血糖及血浆胰岛素、，血糖比值（Ｉ／Ｇ）、，糖耐量曲线下面积、，胰岛素释放曲线下面积均较服药前明显下降。

Objective:To study the effect of cozaar on insulin resistance(ISR) in patients with hypertension (EH). Methods: Oral glucose tolerance test and insulin release test were studied in 25 cases of essential hypertension (EH) before and after taking Cozaar. Results: In the 4th week after taking Cozaar ,the blood glucose、 blood insulin 、 fast insulin/glucose ratio、 the area under glucose tolerance curve and area under insulin release curve in EH was reduced. Conclusions:Cozaar can improve ISR in EH。