摘要
目的:探讨依那普利逆转高血压性心血管改变的机理。方法:给10周龄的自发性高血压大鼠(SHR)饮水中加入依那普利10周,观察SHR的收缩压(SBP)、左心室肥厚和肠系膜小动脉的组织结构改变。结果:(1)收缩压:20 周龄时,SHR 治疗组(SHRen)的SBP:120 ±12 m m Hg,较对照组SHR(SHRc)的血压(196±13m m Hg)显著回降(P< 0.05);(2)LVH的指标变化:1)左心室胶原含量:SHRen 为4.06±0.04 m g 和SHRc(5.84±0.03m g)比较明显下降(P< 0.05);(2)左心室重/体重之比率(LV/BW):SHRen 组为2.22±0.02 比SHRc组(3.32±0.04)显著降低(P< 0.05);(3)SHRen 肠系膜小动脉的病理性组织结构改变,基本恢复正常。结论:依那普利能逆转SHR的高血压。
Objective:To investigate the reversal effect of enalapril on hypertension and cardiovascular changes. Motheds:Treatment of male spontaneously hypertensive rats(SHR) and Wistar Kyoto(WKY) rats with enalapril was carried out by the addition of the drug in the drinking water from 10 to 20 weeks of age.Systolic blood pressure(SBP) was measured weekly until 20 weeks of age. At both 10 and 20 weeks of age,collagen content in left ventricule(LV)、 the ratio of LV/BW, and cardiovascular morphometry were examined. Results:At 20 weeks of age, SBP and collagen in LV and LV/BW were reduced signifcantly in treated SHR( P <0.05). Conclusion:Treatment with enalapril of SHR reverses the development of hypertension and cardio vascular changes in SHR.
出处
《高血压杂志》
CSCD
1999年第4期382-384,共3页
Chinese Journal of Hypertension
关键词
高血压
依那普利
治疗
左心室肥厚
spontaneously hypertensive rat
\ enalapril
\ Left Ventricular hypertrophy
\ collagen