首次发病的重性抑郁障碍患者脑白质异常的弥散张量成像研究

White matter abnormalities in single-episode,medication-naive subjects with major depressive disorder:a voxel-based diffusion tensor imaging study

目的用弥散张量成像的磁共振技术观察首次发病、未用药的重性抑郁障碍患者脑白质的异常。方法对23例重性抑郁障碍患者和21例性别、年龄及受教育程度相匹配的健康对照者进行弥散张量成像的磁共振扫描,采用基于体素的分析方法来研究重性抑郁障碍患者的全脑白质异常。结果与正常对照相比,重性抑郁障碍患者的右侧上纵束、右侧额中回和左侧顶下小叶的脑白质FA值显著降低。结论重性抑郁障碍患者的早期就存在上纵束、右侧额中叶和顶叶的脑白质异常,这些异常可能是重性抑郁障碍发病的重要病理生理机制。

[Objective] In this study,diffusion tensor imaging（DTI） was used to examine white matter abnormalities in single-episode,medication-naive MDD participants.[Methods] DTI data were acquired from 23 MDD and 21 healthy control participants.A voxel-based analysis（VBA） was used to investigate whole brain white matter abnormalities.[Results] Fractional anisotropy was significantly decreased in the right superior longitudinal fasciculus（SLF） within the frontal lobe,right middle frontal and left parietal white matter in the MDD group compared to the healthy group.[Conclusions] Our results demonstrate abnormalities in SLF,middle frontal and parietal white matter in the early stage of MDD and suggest that these abnormalities may play a key role in the pathophysiology of MDD.