瘦素及其受体在胎盘组织中的表达及与新生儿出生体重的关系

Expressions of leptin and its receptor in placenta and their relationship with newborn infant weight

目的探讨瘦素(leptin)及其受体在胎盘组织中的表达及其与新生儿出生体重的关系。方法采用免疫组织化学方法检测leptin和瘦素受体(obR)在22例小于胎龄儿(SGA)和48例适于胎龄儿(AGA)胎盘组织中的表达,分析两组之间表达的差异。结果胎盘组织中leptin和obR的表达呈正相关(r=0.525,P=0.000),SGA组leptin(χ2=4.153,P=0.042)和obR(χ2=9.291,P=0.002)的表达水平均显著低于AGA组。结论胎盘组织中leptin和obR水平的降低可能与SGA的发生有关。

[Objective] To investigate expressions of leptin and obesity receptor in placenta and their relationship with newborn infant weight.[Methods] Expression of leptin and obesity receptor（obR） was evaluated by immunohistochemical staining in 70 cases of placenta [22 cases were small for gestational age（SGA） and 48 cases were appropriate for gestational age（AGA）,then to evaluate difference between the two groups.[Results] The expression of obR was positively correlated with that of leptin in placenta（r =0.525,P =0.000）,and the expression level of leptin and obR in SGA group were significantly lower than that in AGA group（χ2=4.153,P =0.042;χ2=9.291,P =0.002,respectively）].[Conclusion] Decreasing expression level of leptin and obR may have relationship with pathogenesis of SGA.