睡眠剥夺条件下服用咖啡因对情绪情感状态的影响

Effects of caffeine on m ood during sleep deprivation

目的 探讨睡眠剥夺条件下服用咖啡因对情绪情感状态的影响。 方法 ８ 名受试者用药前后自身对照，每名受试者重复５ 次间隔至少１ 周的实验，每次实验中在从６：００ 至次日９：００ 的２７ ｈ 的睡眠剥夺过程中于凌晨１：００ 分别服用安慰剂（食用淀粉１０ ｍ ｇ）或咖啡因（ ２００ ｍ ｇ 或 ３００ｍ ｇ）或苯丙胺（５ ｍ ｇ 或１０ ｍ ｇ），采用随机双盲给药。并在服药前１ ｈ 及服药后１ ｈ、３ ｈ、５ ｈ、７ ｈ 各完成一组情绪情感状态的测试。 结果 与安慰剂组比较，咖啡因能有效地克服睡眠剥夺后情绪情感状态量表（ＰＯＭＳ）中的“有力－好动”（Ｖ）得分的降低（Ｐ＜ ０．０５），克服“疲惫－惰性”（Ｆ）和“困惑－迷茫”（Ｃ）得分的升高（Ｐ＜ ０．０５）；服用咖啡因后主观困倦程度降低（Ｐ＜ ０．０５） 。２００ ｍ ｇ 与３００ ｍ ｇ 咖啡因组间无显著差异（Ｐ＜ ０．０５）。 结论 咖啡因２００ ｍ ｇ 和咖啡因３００ ｍ ｇ

s Objective To investigatethe effectsofcaffeineon m ood during sleep deprivation. Methods Eight healthy nonsm oking m ale college students served as subjects. They underw ent 5 tests in 5 days (once a w eek). During the test, subjects underw ent27 h sustained aw akeness (from 6:00 to 9:00 nextm orning).Tw o capsulesof5 differentcontents (am ylum , 200 m g caffeine, 300 m g caffeine,5 m g am phetam ine and 10 m g am phetam ine) w ere given in double blind w ay at1:00. Tests for profile ofm ood states(POMS) and Stanford Sleepiness Scale (SSS) w ere done 1 h before taking drug and1 h,3 h 5 h,7 h after taking drug. Results Com pared w ith placebo, caffeine can signigi- cantly alleviate the changes of vigor-activity, fatigue-inertia and confusion-bew ilderm ent scores of POMS(P< 0.05), and low erthe SSSscores(P< 0.05).There w as no significantdifference betw een effects oftw o doses ofcaffeine. Conclusions Caffeine atdose of 200 m g or 300 m g is helpfulfor reversalofthe w orsened m ood and sleepiness during sleep deprivation.