期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

一种新的砷暴露标志物-唾液砷 被引量：4

Salivary Arsenic,A New Biomarker of Arsenic Exposure
原文传递
导出
摘要 慢性砷中毒是一种严重危害人类健康的公共卫生疾病,其中毒机制尚不明确且无有效的治疗手段,因此早期的砷暴露筛查尤为重要。找到一种快速、简便的砷暴露检测标志物是预防砷中毒的关键。由于唾液有采样方便,无创伤,易储存,对不同年龄段的人群均适合等一系列优点,近年来唾液标本已广泛的应用到各种疾病及有害因子的诊断和检测当中,包括砷暴露的检测。该文就近年来唾液检测的应用及唾液砷作为砷暴露标志物的可行性等方面研究做一综述。 Arsenism is a serious public health hazard to human health.The mechanism for understanding arsenic toxicity remains vague and there is still no effective treatment for arsenism so far.Finding a quick and simple biomarker of arsenic exposure is crucial to the prevention of arsenism.Because saliva is easy to collect and store,noninvasive,suitable for all age groups,saliva has been widely used in recent years to diagnose various diseases and detect environmental pollutants,including arsenic exposure.This article reviewed the application of saliva testing and the feasibility of salivary arsenic as a biomarker of arsenic exposure.
作者 王大朋 刘建 安艳
机构地区 苏州大医学部放射医学与公共卫生学院
出处 《环境与健康杂志》 CAS CSCD 北大核心 2011年第6期561-563,共3页 Journal of Environment and Health
基金 日本文部科学省日本学术振兴会研究辅助金项目(20390173) 江苏省放射医学与防护重点实验室开放课题(KJS0927) 苏州大学国家自然科学基金预研项目(Q3126982)
关键词 唾液 砷暴露 生物标志物 Saliva Arsenic exposure Biomarker
分类号 R181.3 [医药卫生—流行病学]
  • 相关文献

参考文献31

  • 1Lima DP, Diniz DG, Moimaz SAS, et al. Saliva: reflection of the body [J].Int J Infect Dis, 2010,14: 184-188.
  • 2Haeckel R, Hanecke P. Application of saliva for drug monitoring .An in vivo model for trans membrane transport[J]. Eur J Clin Chem Clin Biochem, 1996, 34:171 - 191.
  • 3Denny P, Hagen FK, Hardt M, et al. The proteomes of human parotid and subm and ibular/sublingual gland salivas collected as theductal secretions [J].J Proteome Res, 2008, 7:1994 - 2006.
  • 4朱远航,王萍,罗敏琪.唾液检测对口干症的临床诊断作用[J].检验医学与临床,2009,6(16):1340-1341. 被引量：2
  • 5Tao R, Jurevic RJ, Couhon KK, et al. Salivary antimierobial peptide expression and dental caries experience in ehildren [J]. Antimicrob Agents Chemother, 2005, 49: 3883-3888.
  • 6Sawamoto Y, Sugano N, Tanaka H, et al. Detection of periodontopathic bacteria and an oxidative stress marker in saliva from periodontitis patients[J]. Oral Microbiol Immunol, 2005, 20: 216-220.
  • 7Liao PH, Chang YC, Huang MF, et al. Mutation of p53 gene codon63 in saliva as a molecular marker for oral squamous cellcarci nomas[J].Oral Oncol, 2000, 36: 272-276.
  • 8Hu S, Yen Y, Ann D, et al. Implications of salivary proteomics in drug discovery - and development : a focus on cancer drug discovery [J]. Drug Discov Today, 2007, 12:911-916.
  • 9Streckfus C, Bigler L, Tucci M, et al. A preliminary study of CA15-3, c-erbB-2,epidermal growth factor receptor, cathepsin-D,and p53 in saliva among women with breast carcinoma [J].Cancer Invest, 2000, 18: 101-109.
  • 10Chien DX, Schwartz PE. Saliva and serum CA 125 assays for detecting malignant ovarian tumors [J]. Obstet Gynecol, 1990, 75: 701-704.

二级参考文献13

  • 1Pajukoski H, Meuman J H, H alonen P, et al. Prevalence of subjective dry mouth and burning mouth in hospitalized elderly patients and outpatients in relation to saliva medication and systemic diseases[J]. Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 2001,92(6) : 641-649.
  • 2Vitali C,Banbardieri S,Jonsson R,et al. Classification criteria for Sogren's syndrome,a revised version of the European criteria proposed by the American-European con sensus group[J]. Ann Eheum Dis, 2002,61 (5) : 554-558.
  • 3Navazesh M, Christensen C, Brightnan V. Clinical criteria for the diagnosis of salivary gland hypofunction[J]. J Dent Res, 1992,71 (5) : 1363-1369.
  • 4Kaufman E, Lamster IB. The diagnostic applications of saliva-a review[J]. Crit Rev Oral Biol Med, 2002,13 (2): 197-212.
  • 5Berkovitch M,Bistritzar T,Aladjem M,et al.Clinical relevance of therapeutic drug monitoring of digoxin and gentamicin in the saliva of children[J].Ther Drug Monit,1998,20:253-256.
  • 6Ding GH,Naora KJ,Nagasako SA,et al.Excretion of ofloxacin into saliva in rats with renal failure[J].J Pharmaco Exp Ther,1998,287(1):31-36.
  • 7Watanabe J,Nakase Y,Urasaki Y,et al.Protein binding effects on salivary excret-ion of Phenobarbital in dogs[J].J Pharmacobio-dyn,1981,4:968-977.
  • 8王昆润,曹全禄.唾液pH值下降时结构性质的变化[J].中国社会医学杂志,2000,17(3):143-144. 被引量：5
  • 9毕伟东,王成艳,王成贤.砷及砷化物与人类疾病[J].微量元素与健康研究,2002,19(2):76-79. 被引量：30
  • 10陈英剑,胡成进,杨道理.唾液检测在疾病诊断中的应用进展[J].山东医药,2002,42(15):60-61. 被引量：6

共引文献3

同被引文献86

引证文献4

二级引证文献13

环境与健康杂志
2011年 第6期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部