枸杞多糖对小鼠肠道上皮内淋巴细胞和杯状细胞数量、分布及对IL-2水平影响

Effect of Chinese Wolfberry(Lycium barbarum) Polysaccharides on Number and Distribution of Intraepithelial Lymphocytes and Goblet Cells and IL-2 Expression in Mice

为了研究枸杞多糖(LBP)对肠黏膜屏障结构的影响,给10只C57BL/J健康小鼠连续灌服枸杞多糖7d后,显微镜观察小肠上皮内淋巴细胞(IEL)、杯状细胞(GC)数量和分布变化及测定肠黏膜白细胞介素-2(interleukin-2,IL-2)水平。结果表明,应用枸杞多糖小鼠的肠黏膜IEL数量和GC的数量明显增加,且有向肠内层移动趋势,同时肠黏膜IL-2水平升高。证实枸杞多糖在一定程度上可促进小鼠小肠黏膜屏障结构趋于完整并提高其免疫功能。

In order to explore the effect of Lycium barbarum polysaccharides（LBP） on intestinal mucosal barrier function in rats,the number and distribution of intraepithelial lymphocytes（IEL） and goblet cells（GC） in 10 C57BL/J mice were observed by light microscope after oral administration with LBP for a week.The results showed that the number of IEL and GC exhibited an obvious increase and these cells moved towards the inner layer of the small intestine.Meanwhile,the IL-2 expression level in the intestinal mucosa also revealed a significant increase.These studies suggested that LBP could promote the integrity of the small intestinal mucosal barrier structure and improve the immune function.