胶原复合支架在血管组织工程中的应用

APPLICATION OF COLLAGEN COMPOSITE SCAFFOLD IN VASCULAR TISSUE ENGINEERING

目的综述胶原与可降解高分子材料复合支架在血管组织工程中的应用,介绍近年来基于胶原材料制备的多层血管支架。方法查阅近年来胶原复合支架作为组织工程血管支架材料的相关文献,并进行综述。结果作为天然血管的结构蛋白之一,胶原因其良好的组织相容性、可降解性以及具有细胞识别信号等特点,广泛应用于血管组织工程。胶原复合高分子材料可制备具生物活性、力学性能良好的血管支架,其中多层血管支架更可在结构和功能上模拟天然血管。结论胶原复合高分子材料是目前血管支架研究的热点,其中多层血管支架已成为研究的新趋势。

Objective To review the application of collagen and biodegradable polymer composite scaffolds in vascular tissue engineering, and describe the multi-layering vascular scaffolds of collagen-based material in recent years. Methods The literature concerning collagen composite scaffold production for scaffold of vascular tissue engineering was extensively reviewed and summarized. Results As one of the structural proteins in natural blood vessel, collagen is widely used in vascular tissue engineering because of good biocompatibility, biodegradability, and cell recognition signal. The vascular scaffolds with biological activity and good mechanical properties can be made by collagen-polymer composite materials. In addition, the structure and function of the natural blood vessel can be better simulated by multi-layering vascular scaffolds. Conclusion Collagen-polymer composite material is the hot spot in the research of vascular scaffolds, and multi- layering vascular scaffolds have a brilliant future.