NK细胞与肝纤维化关系的研究进展

Progress in relationship of NK cell and liver fibrosis

以活化的肝星状细胞为中心的局部免疫微环境在肝纤维化的发展中起着关键作用。而近年来一些研究表明NK细胞可通过产生具有抗纤维化作用的IFN-γ并且直接杀死活化HSCs,起到明显的抗肝纤维化作用。因此,刺激NK细胞活化极可能成为治疗肝纤维化的新途径。

Activated hepatic stellate cells（HSCs） play an important role in the development of liver fibrosis.Recently evidences show that NK cells could directly kill activated HSCs and attenuate liver fibrosis by producing antifibrotic IFN-γ.Stimulating NK activity may potentially be a novel strategy to liver fibrosis treatment.