胰岛素泵治疗糖尿病酮症酸中毒的临床观察

Clinical observation of diabetic ketoacidosis treated with insulin pump

目的探讨胰岛素泵持续皮下注射胰岛素（CSⅡ）疗法对糖尿病酮症酸中毒（DKA）的治疗作用。方法将我院住院的55例DKA患者随机分为胰岛素泵皮下输注组（CSⅡ组，25例）和常规小剂量胰岛素静脉滴注（对照组，30例），分别使用胰岛素泵皮下输注胰岛素和小剂量胰岛素静脉滴注，观察和比较两组患者治疗前后空腹血糖、餐后2h血糖、血糖控制达标时胰岛素用量、到控制满意所需时间、低血糖反应发生率。结果两治疗组血糖达标时间有显著差异，CSⅡ治疗组胰岛素用量及低血糖事件发生率小于常规治疗组，两组比较差异有统计学意义。结论胰岛素泵持续皮下输注胰岛素治疗DKA患者较常规小剂量静脉注射胰岛素疗效更安全、有效。

Objective To investigate the effectiveness of the treatment for diabetic ketoacidosis （DKA） by insulin infused with insulin pump unremittingly and subcutaneously. Methods Fifty -five patients with DKA were divided into the treatment group （25 cases） and the control group （30 cases）, and they were given insulin infused with insulin pump subcutaneously and lowdose intravenous infusion insulin respectively. The average recovering time of blood glucose, blood ketoacidosis and urinary ketoacidosis and the frequency of hypoglycemin incidence were observed in two groups. Results There was no significant difference in the time for blood sugar drop to target and urine acetone body turning to negative in the two groups after treatment. The total dosage of insulin and the incidence rate of low blood sugar were signifi- cantly lower in the treatment group than those in the control group. Conclusions The treatment of insulin pump was more effectively and safely than intravenous insulin infusion in patients with DKA.