摘要
目的探讨阿托伐他汀对急性脑梗死(ACI)患者血清超敏C反应蛋白(hs—CRP)及白细胞介素-6(IL-6)水平以及神经功能的影响。方法将80例ACI患者随机分为阿托伐他汀组(40例)和常规治疗组(40例)。阿托伐他汀组在常规治疗基础上加用阿托伐他汀20mg,每日1次,连续服用4周。检测治疗前后血清h—CRP和IL-6水平,并进行神经功能缺损程度评分(NDS)评定。并以20例健康体检者作为正常对照组。结果ACI患者血清hs—CRP和IL一6水平较正常对照组明显升高(P〈0.05);治疗后两组血清hs—CRP和IL-6水平均较治疗前明显下降(均P〈0.05),且阿托伐他汀组较常规治疗组下降明显(P〈0.05);两组NDS评分较治疗前明显下降(均P〈0.05),且阿托伐他汀组较常规治疗组下降明显(P〈0.05)。结论阿托伐他汀能明显降低ACI患者血清hs—CRP和IL-6水平,并有助于ACI患者的神经功能恢复。
Objective To explore the effect of atorvastatin on the level of serum high sensitivity C - reactive protein ( hs - CRP) and interleukin - 6 ( IL - 6) in patients with acute cerebral infarction (ACI). Methods Eighty patients with ACI were randomly divided into the atorvastatin therapy group ( n = 40) and the conventional therapy group ( n = 40). At the basic of conventional therapy, the atorvastatin therapy group was treated with atorvastatin 20 mg/d. Both groups were treated for 4 weeks. The levels of serum hs- CRP and IL-6 were measured and the scores of neurological deficit(NDS) were e- valuated before and after treatment. A healthy control group which approximately matched the experimental group included 20 cases. Results The levels of serum hs - CRP and IL - 6 in both two groups after 14 d treatment were significantly lower than those before treatment (all P 〈 0.05) , and the level of ser- um hs- CRP and IL -6 in atorvastatin therapy group was significantly lower than that in conventional therapy group ( P 〈0.0fi). NDS of both groups after treatment were lower than those before treatment (P 〈 0.05) , and the scores of atorvastatin therapy group were significantly lower than those of conventional therapy group ( P 〈 0.0fi). Conclusions Atorvastatin can significantly decrease the level of serum hs -CRP and IL- 6, and it can promote the neurological ruction recovery in the patients with ACI.
出处
《中国实用医刊》
2011年第14期50-52,共3页
Chinese Journal of Practical Medicine
关键词
阿托伐他汀
脑梗死
超敏C反应蛋白
白细胞介素-6
Atorvastatin
Cerebral infarction
High - sensitivity C - reactive protein
Interleukin - 6