中药灌肠联合药浴早期干预新生儿高胆红素血症的临床研究

Clinical Study on Early Intervention of Enteroclysm Combined with Medicated Bath of Chinese Materia Medica on Neonatal Hyperbilirubinemia

目的:观察中药灌肠联合药浴对新生儿高胆红素血症的早期干预效果。方法:选择有高胆红素血症倾向患儿180例,随机分为3组。其中对照组A在新生儿出生后24h内给予苯巴比妥钠口服;对照组B给予新生儿退黄合剂口服;观察组给予新生儿退黄洗剂药浴联合中药灌肠。动态监测每24h各组皮测胆红素水平,测定72h血清胆红素水平,比较出生72h后新生儿高胆红素血症的发生率。结果:观察组与对照组A比较,皮测胆红素值、血清胆红素值及病理性黄疸的发生率均下降,差异有统计学意义(P<0.01或P<0.05);观察组与对照组B比较,出生72h血清胆红素水平、病理性黄疸的发生率下降,差异亦有统计学意义(P<0.05)。结论:中药灌肠联合药浴可有效防止新生儿高胆红素血症的发生,同时克服了新生儿口服药物的不便。

OBJECTIVE：To observe the early intervention effect of enteroclysm combined with medicated bath of Chinese materia medica on neonatal hyperbilirubinemia.METHODS：Neonatus met the inclusion criteria of neonatal hyperbilirubinemia were randomly divided into 3 groups：control group A,control group B and observation group（n=60）.Control group A were given oral dose of phenobarbital sodium within 24 h,control group B were given oral dose of Newborn tuihuang mixture and observation group were given the enteroclysm combined with medicated bath of Chinese materia medica.The transcutaneous bilirubin levels were detected every 24 h,the serum bilirubin（SB） levels were detected in 72 h.The incidence rates of hyperbilirubinemia were compared among 3 groups 72 h after birth.RESULTS：The transcutaneous bilirubin,serum bilirubin and the incidence rate of pathological jaundice in observation group were decreased significantly,compared with control group A,there was statistical significance（P0.01 or P0.05）.Compared with control group B,the incidence rate of pathological jaundice in observation group were also decreased significantly,there was statistical significance（P0.05）.CONCLUSION：The early intervention of the enteroclysm combined with medicated bath of Chinese materia medica on the neonatal hyperbilirubinemia is effective,and it is more convenient than oral administration.