摘要
目的:观察多西他赛联合奥沙利铂治疗晚期头颈部肿瘤的疗效及不良反应。方法:52例晚期头颈部肿瘤患者按住院号随机分为A组26例和B组26例。A组多西他赛75mg/m^2,静脉滴注,第1天;奥沙利铂130mg/m^2,静脉滴注,第1天;3周为1周期,连用2周期~4周期。B组顺铂25mg/m^2,静脉滴注,第1天~3天;5-氟脲嘧啶3.5g/m^2,用输液泵连续滴注5天;3周为1周期,连用2周期~4周期。两组均在化疗结束2周后评价疗效。结果:52例均可评价疗效,每例患者均完成2周期以上化疗。有效率A组为53.8%(14/26),B组为42.3%(11/26),两组差异无统计学意义(P>0.05)。1年生存率A组为42.3%,B组为30.8%,两组差异无统计学意义(P>0.05)。生活质量提高A组50.0%(13/26),B组26.9%(7/26),两组差异有统计学意义(P<0.05)。骨髓抑制发生率两组差异无统计学意义(P>0.05)。胃肠道反应A组较B组低(P<0.05)。结论:多西他赛联合奥沙利铂方案治疗晚期头颈部肿瘤的缓解率较高,而毒性相对较低。
Objective: To observe the effects and side effects of docctaxel combined with oxaliplatin in treatment of advanced head and neck tumors. Methods: 52 patients with advanced head and neck cancer were randomly divided into A group (26 cases)and B group(26 cases), A group accepted docetaxel 75mg/m2 intravenously on day 1, oxaliplatin 130 mg/m2 intravenously, day 1, every 3 weeks as 1 cycle, totally 2 to 4 cycles ; B group accepted cisplatin 25mg/m2 intravenously, d1 - d3 , fluorouracil 3.5g/m2 , continuous infusion with infusion pump for 5days, 3 weeks as 1 cycle, altogether 2 to 4 cycles. Effect was evaluated two weeks after treatment. Results: 52 cases were available for each patient completed at laset two cycles of chemotherapy. Efficacy of A group was 53.8% ( 14/ 26), B group 42.3% (11/26) (P 〉0.05). 1-year survival rate of A group was 42.3%, B group 30.8% (P 〉0.05). Life quality of 50. 0% (13/26) of patients in A group improved while in B group 26. 9% (7/26)improved( P 〈 0. 05 ). There was no significant difference of the incidence of myelosuppression between two groups(P 〉 0. 05 ). The gastrointestinal side effect of A group was lower than that of B group(P 〈 0. 05). Conclusion: Docetaxel plus oxaliplatin regimen can get high rimission rate in the treatment of advanced head and neck tumors with mild toxity.
出处
《肿瘤预防与治疗》
2011年第4期157-159,共3页
Journal of Cancer Control And Treatment
关键词
头颈部肿瘤
多西他赛
奥沙利铂
治疗
Head and Neck Cancer
Docetaxel
Oxaliplatin
Treatment