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非甾体类抗炎药联合他汀类药的肿瘤化学预防作用

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摘要 肿瘤的化学预防是通过直接调节基因癌变的某些过程,如预防自由基对DNA损伤、抑制上皮细胞过度增殖或调节上皮细胞分化和凋亡来达到阻止癌变发生的目的。目前有许多化学预防药物正在开发和试验的不同阶段,主要有视黄醇、类胡萝卜素、激素类药物、经典以及非经典抗氧化剂,目前研究比较多的是非甾体抗炎药(NSAIDs)。
出处 《肿瘤预防与治疗》 2011年第4期205-208,共4页 Journal of Cancer Control And Treatment
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  • 1Singh DK, Lippman SM. Cancer chemoprevention. Part 2: hot-mones, nonclassic antioxidant natural agents, NSAIDs, and other agents [J]. Oncology,1998,12(12) :1787-1800.
  • 2Omer GA, Dashwood WM, Blum CA, et al. Suppression of tu- morigenesis in the Apc(min) mouse: down-regulation of beta- catenin signaling by a combination of tea plus sulindac [ J]. Carci- nogenesis,2003,24 ( 2 ) :263- 267.
  • 3Mladenova D, Daniel J J, Dahlstrom JE, et al. The NSAID sulin- dac is chemopreventive in the mouse distal colon but carcinogenic in the proximal colon [ J ]. Gut, 2011,60 ( 3 ) : 350 - 360.
  • 4Kulp SK, Yang YT, Hung CC, et al. 3-phosphoinositide-depend- ent protein kinase-1/Akt signaling represents a major cyclooxygen- ase-2-independent target for celecoxib in prostate cancer cells[ J]. Cancer Res. 2004,64(4) : 1444-51.
  • 5Maier TJ, Janssen A, Schmidt R, et al. Targeting the beta-cate- nin/APC pathway: a novel mechanism to explain thecyclooxygen- ase-2-independent anticarcinogenic effects of celecoxib in human colon carcinoma cells [ J ]. FASEB J, 2005,19 ( 10 ) : 1353 - 1355.
  • 6Dihlmann S, Klein S, Doeberitz Mv MK. Reduction of beta-cate- nin/T-cell transcription factor signaling by aspirin and indometha- cin is caused by an increased stabilization of phosphorylated beta- catenin[ J]. Mol Cancer Ther,2003,2(6) :509-16.
  • 7Alberts DS, Lee Hixson, Dennis Ahnen. Do NSAIDs exert their colon cancer ehemoprevention activities through the inhibition of mueosal prostaglandin synthetase? [ J]. Cell Biochem, 1995,59 (22) :18-23.
  • 8Lee HC, Park IC, Park M J, et al. Sulindac and its metabolites in- hibit invasion of glioblastoma cells via down-regulation of Akt/PKB and MMP-2[J]. J Cell Biochem,2005,94(3) :597-610.
  • 9Borthwiek GM, Johnson AS, Partington M, et al. Therapeutic lev- els of ~pifin and salicylate directly inhibit a model of angiogenesis through a Cox-independent mechanism [ J]. FASEB J, 2006,20 (12) :2009-2016.
  • 10Giardiello FM, Hamilton SR, Krush A J, et al. Treatment of colonic and rectal adenomas with sulindac in familial adenomatous polypo- sis[J]. N Engl J Med,1993,328(18) :1313-1316.

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