利培酮与舒必利对精神分裂症患者血脂代谢的影响

The side-effects of Risperidone and Sulpiride on the lipid metabolism in the schizophrenic patients

目的：探讨利培酮和舒必利对首发精神分裂症患者血脂代谢的影响。方法：对2008年1月~2010年1月我院住院的精神分裂症患者547例测定利培酮和舒必利治疗8周前后的血胆固醇（TC）及三酰甘油（TG）浓度。结果：①利培酮治疗后,血胆固醇及血三酰甘油明显升高（t=2.94,P=0.003;t=2.56,P=0.011）,且男性患者组升高较女性明显（t=2.47,P=0.015;t=2.29,P=0.023）;②舒必利组治疗后血胆固醇及血三酰甘油明显升高（t=2.35,P=0.019;t=2.16,P=0.032）,且女性TG升高的程度显著大于男性患者（t=3.11,P=0.002）。③利培酮对于血胆固醇及三酰甘油的影响大于舒必利（t=3.24,P=0.001;t=2.27,P=0.021）。结论：利培酮使血胆固醇及三酰甘油水平升高,对男性影响大。舒必利使血胆固醇及三酰甘油水平升高,对女性影响大。利培酮对TC的影响大于舒必利。

Objective：To explore the side-effects of Risperidone and Sulpiride on the lipid metabolism in schizophrenic patients.Methods：547 schizophrenic inpatients were recruited from January 2008 to January 2010.The concentrations of TC and TG after 8 week Risperidone or Sulpiride treatment were detected.Results：①After Risperidone treatment,TC and TG concentrations were significantly increased（t=2.94,P=0.003;t=2.56,P=0.011）.Moreover,male patients had the more severe side-effects on the lipid metabolism than female（t=2.47,P=0.015;t=2.29,P=0.023）.②After Sulpiride treatment,TC and TG concentrations were significantly increased（t=2.35,P=0.019;t=2.16,P=0.032）.Moreover,TG concentrations of female patients increased more highly than those of male（t=3.11,P=0.002）.③Risperidone had the more effects on TC and TG than Sulpiride（t=3.24,P=0.001;t=2.27,P=0.021）.Conclusion：Risperidone could raise the TC and TG concentrations,and more greatly in male patients.Sulpiride raises the TC and TG concentrations,and more greatly in female patients.Risperidone has the more effects on TC and TG than Sulpiride.