肠易激综合征和非酒精性脂肪肝的相关性探讨

The discussion of correlation between irritable bowel syndrome and non-alcoholic fatty liver disease

目的：探讨肠易激综合征（IBS）和非酒精性脂肪肝（NAFLD）的相关性。方法：选取2007年3月~2009年3月门诊体检的200例居民为研究对象,在全项体检结果基础上筛选出NAFLD合并IBS组患者25例,单纯NAFLD或IBS组患者36例。常规实验室生化检查,测定空腹12 h后静脉血糖、血脂含量;应用多通道胃肠功能检测仪测定患者直肠初始感觉阈值（first sensation volume,FSV）、排便时阈值（defecating sensation volume,DSV）、排便窘迫时阈值（maximum tolerable volume,MTV）和最大容量时的感觉阈值（painful sensation volume,PSV）。结果：NAFLD合并IBS组中并发合并高血压、肥胖、血脂异常、糖尿病和消化系统疾病的患者均较单纯NAFLD或IBS组高;当NAFLDIBS后,血脂异常情况加剧,增加了疾病的危险因素;NAFLD合并IBS组后患者胃肠容量感觉阈值均较单纯NAFLD或IBS组低,两组比较,差异有统计学意义（P〈0.05）。结论：非酒精性脂肪肝的发病和肠易激综合征相关性密切,两者共同作用不仅能引起代谢功能高度异常,还会加速炎症引发人体病理生理发生改变,诱发心脑血管疾病和消化系统疾病。

Objective：To discuss the correlation between irritable bowel syndrome（IBS） and non-alcoholic fatty liver disease（NAFLD）.Methods：The residents of 200 cases who did physical examination in our clinic were selected in our study from March 2007 to March 2009.All the subjects were divided into two groups with results of physical examination,NAFLD combined IBS group was 25 patients and the simple NAFLD or IBS group was 36 cases.The glucose and lipid levels of venous blood after 12 h fasting venous were determined in routine laboratory biochemical tests.The first sensation volume（FSV）,defecating sensation volume（DSV）,maximum tolerable volume（MTV） and the painful sensation volume（PSV） were measured with multi-channel detection of gastrointestinal function.Results：The hypertension,obesity,dyslipidemia,diabetes and patients with digestive diseases in NAFLD combined IBS group were more than the simple NAFLD or IBS group;when NAFLD was combined with IBS,disease risk factors were increased;the perception threshold in patients with gastrointestinal capacity of patients in NAFLD combined IBS group were lower than the simple NAFLD or IBS group;the results was significant different between two groups（P0.05）.Conclusion：The correlation between irritable bowel syndrome and non-alcoholic fatty liver disease is close.Not only the function of metabolic is highly abnormal in NAFLD combined IBS group,but also human pathophysiology is changed just because the inflammatory is accelerated.The cardiovascular diseases and digestive diseases were also induced in NAFLD combined IBS group.