股骨促结缔组织增生性纤维瘤2例报告并文献复习

Desmoplasic fibroma of the femur:two cases report and literature review

目的探讨股骨促结缔组织增生性纤维瘤(DF)的临床病理特征及诊断与鉴别诊断。方法对2例股骨DF进行病理形态和免疫组化观察,结合临床资料进行分析并复习相关文献。结果组织学特点:肿瘤由梭形瘤细胞和大量胶原构成,胶原纤维密集而粗大,呈波浪状或束状,瘤细胞核形态温和,肿瘤多呈浸润性生长。免疫组化:瘤细胞-βcatenin(2/2)、Vimentin(2/2),Desmin、SMA局灶(+)。结论骨DF具有较强的局部侵袭能力,切除不彻底容易复发,应手术广泛全切。联合检测-βcatenin、SMA、Vim、Desmin等标记物对骨DF诊断和鉴别诊断具有重要意义。

Objective To investigate the clinicopathological features of desmoplastic fibroma（DF） of femur.Methods Two cases of DF of femur were observed by HE and immunohistochemical staining,and analyzed with their clinical features.Results Microscopically,the tumor consisted of elongated spindle cells and thick wavy collagen bundles.The spindle cells had bland nuclei and mitosis was not found.Immunohistochemically,the spindle cells were positive for β-catenin（2/2）,AR（2/2）,ER（1/2）,PR（2/2）,focally positive for SMA and Desmin.Conclusion DF of femur is a rare tumor with strongly local aggressiveness and high potential for recurrence after incomplete resection.Complete resection is the best treatment.β-catenin,SMA,Vim,Desmin joint detection in DF of bone has an important application value in the diagnosis and the differential diagnosis.