摘要
目的探讨老年2型糖尿病患者心率变异性(heart rate variability,HRV)与血清基质金属蛋白酶-9(Matrix-metallo proteinase 9,MMP-9)水平变化。方法选取2010年住院治疗的老年2型糖尿病患者42例,再选取老年非糖尿病患者40例,分为糖尿病组和对照组,并行24 h动态心电图检查,测定HRV,包括窦性心搏R-R(NN)间期的标准差(SDNN)、全程记录中每5 min NN间期平均值的标准差(SDANN)、相邻NN间期差值的均方根(MSSD),检测血清MMP-9指标,并对糖尿病组的HRV与MMP-9行线性相关分析。结果糖尿病组HRV计数值显著低于对照组(P<0.05),而MMP-9值较对照组显著升高(P<0.05),HRV与MMP-9具有显著的负相关性(r=-0.24,r=-0.18,r=-0.22,P<0.05)。结论糖尿病患者心脏自主神经功能的改变和MMP-9的变化具有相关性。
Objective To explore the change of heart rate variability(HRV) and serum matrixmetallo proteinase-9(MMP-9) in aged patients with type-2 diabetic.Methods Totally 42 aged patients with type-2 DM were enrolled in this study who were selected from the inpatients and another 40 non-diabetic matched individuals were recruited as contro1.Their serum MMP-9 and 24 hour electrocardiography were examined.HRV was assessed by calculating the indices based on statistical operation on RR intervals(time domain analysis) from 24 hour Hoher recording.including:standard deviation of normal to normal RR intervals(SDNN),standard deviation of 5 minute mean RR intervals(SDANN) and square root of differences between adjacent NN intervals (rMSSD).Linear correlation analysis was carried out between their serum MMP-9 and HRV.Results HRV parameters of type 2-DM patients were significantly lower than those of non-diabetic patients.But MMP-9 values were significantly higher than those of control.Linear correlation analysis indicated that HRV was in a positive corelation with MMP-9 in type 2-diabetic aged patients.Conclusion Altered autonomic nervous function may be associated with altered serum MMP-9 in aged patients with type 2-diabetes mellitus.
出处
《中国误诊学杂志》
CAS
2011年第19期4548-4550,共3页
Chinese Journal of Misdiagnostics
关键词
糖尿病
2型/病理生理学/代谢
心率
明胶酶B/代谢
Diabetes Mellitus
Type 2/metabolism/physiopathology
Heart Rate
Gelatinase B/metabolism