丹参对急性感染性腹膜炎患者内皮素水平的影响

Effect of Radix Salviae Miltiorrhizae on Serum Endothelin in Patients with Acute Infectious Peritonitis

目的:了解急性感染性腹膜炎患者的血清内皮素水平及丹参对其影响。方法:通过放免分析法检测84 例急性感染性腹膜炎患者血清内皮素水平及丹参对其作用。结果:急性感染性腹膜炎患者血清内皮素水平(295-4±86-2ng/L) 较对照组(73-1±28-6ng/L)显著升高( P<0-01) ,给予丹参治疗3 d 后其血清内皮素水平(116-5±32-7ng/L) 较急性感染性腹膜炎患者明显降低( P< 0-05) 并接近对照组水平( P> 0-05) 。结论:内皮素参与腹腔感染发病过程中的炎性反应改变,丹参具有抑制内皮素合成分泌作用,或加速其由体内的清除,丹参抑制内皮素水平的升高可能成为其扩张血管的药理作用机制之一。

To find out the levels of serum endothelinin cases of acute infectious peritonitis and after treated with radix salviae miltiorrhizae.Methods:To determine the levels of serum endothelin in 84 cases of acute infectious peritonitis and after treated with radix salviae miltiorrhizae by radioimmunoassay.Results:serum endothelin concentration increased significantly in patients with acut infectious peritontis,and decreased after 30 days treatment with radix salciae mlitiorrhizae.Conclusion:Vaso dilatory effect of radix salviae miltiorrhizae is accompanied with the decreasing of endothelin concentration.