燃煤型砷中毒患者体内无机砷及相关因素对病情的影响

Influence of Inorganic Arsenic on the Condition of the Patients with Arsenism Caused by Burning Coal and other Related Factors

通过分析燃煤型砷中毒病区人群尿总砷（Ｔｏｔ－ Ａｓ） 、尿无机砷（Ｉｎ － Ａｓ） 、无机砷／ 总砷比值（Ｉｎ － Ａｓ／Ｔｏｔ－ Ａｓ） 和发砷以及相关因素对病情的影响，发现患者体内砷负荷的累积性增加及机体解毒能力的逐渐下降可能是砷中毒病情逐渐加重的原因之一。病区居民长期燃用高砷煤致空气、食品严重污染以及改灶措施不彻底，是导致新发病人不断出现、病情继续发展及皮肤癌逐渐增加的原因。研究初步揭示砷中毒患者无机砷代谢研究的必要性，并对砷中毒综合防治措施提出建议。

This paper analyzed the influence on arsenism of total arsenic (Tot-As) and inorganic arsenic (In-As) in urine, the ratio of In-As to Tot-As(In-As/Tot-As), arsenic in hair and other related factors. The results showed that the increased accumulation of arsenic and the gradual decrease of detoxication in the patients might aggrevate arsenism.Severe arsenic pollution in air and food caused by burning hyperarsenic coal daily for long time, inferior improvement of stoves, poor supervision, less-developed economy and culture were the reasons for the continuous appearance of new arsenism patients, continuous deterioration of clinical manifestations of arsenism and the gradual increase of skin cancer. This paper preliminarily revealed the necessity to study In-As metabolism of the patients and made some suggestions for the comprehensive prevention and treatment of arsenism.