血清胆碱酯酶活性在肝病时的变化及其相关性

The Variety and Correlation Analysis of Plasma Cholinesterase Activity in Hepatosis

用碱性羟胺比色法测定１２４ 例肝脏疾病患者及４５ 例健康人的血清胆碱酯酶（ＣＨＥ） 活力，并同时测定血清总蛋白、白蛋白及谷丙转氨酶（ＡＬＴ） 活力。结果显示：肝脏疾病患者血清胆碱酯酶与正常对照比较活力降低，且以肝癌患者降低量为显著，其降低顺序为肝癌＞ 肝硬化＞ 慢性肝炎＞ 急性肝炎。肝脏疾病患者血清ＣＨＥ 活力与血清蛋白质含量、ＡＬＴ 的直线相关分析结果为：ＣＨＥ与总蛋白、白蛋白之间呈正相关。相关系数分别为：ｒ ＝ ０－９７３ ８ 、Ｐ＜ ０－０１ ，ｒ＝ ０－９７４ ７ 、Ｐ＜ ０－０１ 。与球旦白呈负相关，ｒ＝ － ０－９２８ ５ 、Ｐ＜ ０－０５ 。与ＡＬＴ 无显著相关性，ｒ＝ ０－３６２ ６ ，Ｐ＞ ０－１０ 。故肝功能检测时，测定ＣＨＥ、总蛋白、球蛋白、ＡＬＴ，并探讨它们之间的相关性，具有重要意义。

Plasma cholinesterase activity (CHE) was measured by hydroxylammonium chloride method and total protein concentration, albumin concentration and alanine aminotransferase activity were measured by clinical routine methods in 124 samples of hepatosis patients and 45 samples of normal persons. The results showed that CHE in hepatosis group was lower than normal group. CHE in the group with liver carcinoma was markedly lower. The decrease sequences were liver carcinoma group >cirrhosis group>chronic hepatitis group>acute hepatitis group. Linear correlation analysis between CHE and (total protein, or albumin, or alanine amino transferase activity (ALT) showed that CHE had positive correlation with total protein and albumin, r=0 973 8(P<0 01) and r=0 974 7(P<0 01) respectively. Otherwise CHE had negetive correlation with globulin, r=-0 928 5,P<0 05 and had zero correlation with ALT, r=0 3626,P>0 10。