“慢肾康”对纤维化肾组织基质成分的影响

The Influence of Man Shen Kang on the matrix Components of Fibrotic Kidney

为进一步了解“慢肾康”减轻肾纤维化的机制，在检测肾组织形态的基础上，用免疫组化方法了分析肾组织基质成分的变化。发现、治疗组动物肾小球中纤维连接蛋白沉积明显少于对照组，而胶原Ⅳ型的减少不显著。肾间质中纤维连接蛋白，胶原Ⅲ型和Ⅳ型也减少，但两组间无显著性差异。研究表明“慢肾康”通过减少纤维连接蛋白在肾小球内的沉积而减轻肾小球纤维化程度。

In orderto understand fertherthe mechanism of Chinese medicine- Man Shen Kang on the reduction ofrenalfibrosis,the bistology and matrix componentsof kidneytissue wereanalysed by im munohistochemistry methodin rats with subtotalnephrectomy.Resultsshowedthatdeposition offibronectin in glomeruli of rats treated with Man Shen Kang was much less than that in glomeruliofratsincontrolgroup ,butthe differenceofcollagen Ⅳdepositionin glomeruli was not significant between thetwo groups. No significant differences offibronectin ,collagen Ⅲand Ⅳ intheinterstitium of the kidney were observed within control and treated groups though these matrix componentsin treated group seemd lessthan thosein control group. Our study suggests that Man Shen Kang can reduce the deposition offibronectin in glomeruli of rats with subtotal nephrectomy and thereforeimprovesthe glomerularfibrosis.