氟比洛芬口服混悬剂的兔药物动力学及其生物利用度

Study on pharmacokinetics and bioavailability of flurbiprofen suspension in rabbits

目的:研究氟比洛芬口服给药的药物动力学及生物利用度。方法:利用HPLC法测定氟比洛芬的血药浓度,以交叉给药方式分别给予家兔注射剂和口服混悬剂并且对其药物动力学和生物利用度进行研究。结果:氟比洛芬在家兔体内药动学静脉注射符合二室开放模型,口服符合一室开放模型,氟比洛芬口服混悬剂的绝对生物利用度为61.9%。结论:在进行氟比洛芬剂型研究时应注重提高其口服制剂的生物利用度。

OBJECTIVE:To study the pharmacokinetics and bioavailabilities of flurbiprofen suspension.METHODS:A reversed phase HPLC was established to determine serum flurbiprofen concentration,the pharmacokinetics and bioavailability of FP were investigated in 6 rabbits.RESULTS:The results showed that the pharmacokinetics of FP conformed to two compartment open models after injective administration of FP, and the pharmacokinetics of FP conformed to one compartment open models after oral administration, the bioavailability of the suspension against the injection was 61.9% .CONCLUSION:Improving the bioavailability of FP preparation should be considered.