氯磷定给药时效和量效的关系

Relationship between on time and quantity effectiveness of pyraloxime

目的:优选氯磷定给药时机和给药剂量。方法:对40例有机磷农药中毒患者进行氯磷定给药时效和给药量效分析。结果:给药时机在中毒0～6h,给药量效差异显著。给药时机在中毒6～9h,给药量效差异不显著。给药剂量在0.5～7.0g,给药时效差异显著。结论:在中毒0～6h给药剂量越大疗效越好,最佳给药剂量是5.0～7.0g。给药时机越早越好,最佳给药时机是在中毒0～3h。中毒6h以上,给药剂量大小均无明显疗效。

OBJECTIVE:To optimize the time and dose of pyraloxime administration.METHODS:The effectiveness of time and quantity of the drug was analysed for 40 cases of organophosphorus poisoning.RESULTS:There were significant difference in the effectiveness due to quantity of the drug given for 0～6 hours poisoning,and not for 6～9 hours.There were significant difference in the effectiveness due to the administration time with dose at 0.5 ～ 7.0 g.CONCLUSION:For 0～6 hours with poisoning,the more dose given ,the more cholinesterase vitality increased.The optimum dose was 5.0 ～ 7.0 g.The earlier opportunity of the drug given was vitality restored.The optimum was 0～3 hours with poisoing.Over 6 hours with poisoning,there was no difference in the effectiveness of the drug given with different dose.