CD10、Survivin在弥漫大B细胞淋巴瘤中的表达及临床意义

Expression of CD10 and survivin in diffuse large B cell lymphoma and its significances

目的探讨CD10、Survivin在弥漫大B细胞淋巴瘤(DLBCL)组织中的表达及其与临床特征、疗效、生存率的关系。方法 DLBCL石蜡标本53例,利用组织芯片免疫组化检测CD10、Survivin的表达情况,并进行临床预后分析。结果 (1)CD10的表达与性别、年龄、B症状、血清LDH水平、结外浸润无相关性,与临床分期有明显相关性。Survivin的表达与此均无相关性。(2)CD10高表达组完全缓解率明显高于低表达组。Survivin高表达组与低表达组差异无统计学意义。(3)CD10低表达患者的生存期明显低于高表达者,Survivin阳性患者的生存率明显低于阴性者。结论 CD10与Survivin可作为DLBCL的疗效和预后指标。

Objective To investigate the expression of CD10 and survivin in diffuse large B cell lymphoma（DLBCL） tissues and the relationship with clinical characteristics,efficacy,survival.Methods 53 cases of DLBCL paraffin samples were detected the expression of CD10 and survivin using tissue microarray immunohistochemistry,and were analyzed clinical prognosis.Results（1）There was no relationship between the expression of CD10 and gender,age,B symptoms,serum LDH level,extranodal invasion,and the significant correlation with clinical stage.There was no relationship between survivin and these.（2）The complete remission rate in the CD10 high expression group was significantly higher than the low expression group.There was no significant difference between survivin high expression group and low expression group.（3）The survival of patients in CD10 low expression group was significantly lower than high expression group.The patient＇s survival rate in survivin-positive group was significantly lower than the negative group.Conclusion CD10 and survivin may be prognostic indicators and curative effects of DLBCL.