摘要
脑缺血是许多脑血管疾病的共同特征,急性短暂脑缺血也是许多脑血管疾病的先兆。本文研究证明,体感诱发电位(SEP) 的时频分布对缺血脑损伤十分敏感,与缺血性脑血管疾病有密切关系。本文建立了SD 大鼠局灶性缺血脑损伤实验模型,在用一种高分辨率的时频分析方法- 离散Gabor 谱(DGS) 分析SEP的基础上,对局灶性缺血脑损伤进行了研究,发现在局灶性缺血早期,损伤区域与非损伤区域SEP的时频特征即具有明显的不同,可以区分出缺血损伤区域与非损伤区域。时频分析的结果与我们对同一实验对象的热休克蛋白(HSP)表达分析结果相一致。文中定义了能量中心(COP) 和能量重心( WCOP) 。
Our study showed that the time frequency distribution of somatosensory evoked potential(SEP) was very sensitive to cerebral ischemia. SD rats were used in the animal experiment, and a model of SD rat focal cerebral ischemia was presented. Based on the Discrete Gabor Spectrogram(DGS), SEP of brain ischemia was analyzed. The study proved that the time frequency feature of SEP signals in the ischemic area was obviously different from those of normal areas, and the two areas could be clearly distinguished by analyzing their SEP signals in time frequency domain. The time frequency analysis results were verified by the Heat Shock Protein(HSP) test. Center of Power(COP) and Weight Center of Power(WCOP) were defined. Our study might be used as a quantitative method to detect focal cerebral ischemia in the earlier phases.
出处
《中国生物医学工程学报》
CAS
CSCD
北大核心
1999年第4期374-382,388,共10页
Chinese Journal of Biomedical Engineering
基金
国家自然科学基金
西安交通大学博士学位论文基金
国家教育部博士点基金
关键词
局壮性
脑缺血
诊断
无创诊断
Cerebrovascular disease
Focal brain ischemia injury
Detect
Somatosensory Evoked Potential(SEP)
Time frequency analysis
Noninvasive