局灶性缺血脑损伤的无创诊断技术研究

THE STUDY OF NONINVASIVE DETECTING THE FOCAL CEREBRAL ISCHEMIA

脑缺血是许多脑血管疾病的共同特征，急性短暂脑缺血也是许多脑血管疾病的先兆。本文研究证明，体感诱发电位（ＳＥＰ） 的时频分布对缺血脑损伤十分敏感，与缺血性脑血管疾病有密切关系。本文建立了ＳＤ 大鼠局灶性缺血脑损伤实验模型，在用一种高分辨率的时频分析方法－ 离散Ｇａｂｏｒ 谱（ＤＧＳ） 分析ＳＥＰ的基础上，对局灶性缺血脑损伤进行了研究，发现在局灶性缺血早期，损伤区域与非损伤区域ＳＥＰ的时频特征即具有明显的不同，可以区分出缺血损伤区域与非损伤区域。时频分析的结果与我们对同一实验对象的热休克蛋白（ＨＳＰ）表达分析结果相一致。文中定义了能量中心（ＣＯＰ） 和能量重心（ ＷＣＯＰ） 。

Our study showed that the time frequency distribution of somatosensory evoked potential(SEP) was very sensitive to cerebral ischemia. SD rats were used in the animal experiment, and a model of SD rat focal cerebral ischemia was presented. Based on the Discrete Gabor Spectrogram(DGS), SEP of brain ischemia was analyzed. The study proved that the time frequency feature of SEP signals in the ischemic area was obviously different from those of normal areas, and the two areas could be clearly distinguished by analyzing their SEP signals in time frequency domain. The time frequency analysis results were verified by the Heat Shock Protein(HSP) test. Center of Power(COP) and Weight Center of Power(WCOP) were defined. Our study might be used as a quantitative method to detect focal cerebral ischemia in the earlier phases.