摘要
目的:比较米非司酮与妈富隆对围绝经期功能失调性子宫出血的疗效。方法:2009年1月~2010年2月收治20例围绝经期功能失调性子宫出血的患者,服用米非司酮12.5mg,每天1次,连服3个月,作为实验组。将同期就诊的围绝经期功能失调性子宫出血患者23例作为对照组,应用妈富隆治疗。观察两组疗效和不良反应情况,进行比较。结果:妈富隆治疗功血的有效率高,使患者恢复正常月经,但复发率较高;而米非司酮是导致患者闭经,两者治疗效果不一样。在不良反应方面,妈富隆组的不良反应发生率要低于米非司酮组。结论:雌孕激素合剂妈富隆治疗围绝经期功血有效率高,完全止血时间短,可调整月经周期,但复发率也高;而米非司酮可以导致闭经,甚至直接进入绝经。两者在作用机制上不同,疗效上各有利弊。
Objectives:To compare the curative effects of mifepristone with marvelon on treatment of PDUB. Methods: Twenty patients with PDUB, which sought medical service in gynecology clinic of Chaozhou city central hospital from January 2009 to February 2010, They taked medicine of mifepristone once a day with 12. 5rag for three months, respectively. Twenty - three patients with PDUB, which were treated with medi- cine of marvelon in gynecology clinic of Chaozhou city central hospital from January 2009 to February 2010, were selected as a control group to compare the curative effects and adverse reactions with that of mifepristone group. Results: Marvelon is highly effective in treatment of PDUB with restoring normal menstruation, but the recurrence rate was high. Mifepristone can lead to amenorrhea in patients. The curative effects of twodrugs are different. The incidence of adverse reactions in marvelon group was lower than that in mifepristone group. Conclusions: Marvelon, a mixture of estrogen and progesterone, treats PDUB with a high effective rate and the short time in stop bleeding, and can adjust the menstrual cycle, but the recurrence rate is also high. Mifepristone can cause amenorrhea, or even directly into the menopause. The mechanisms of marvelon and mifepristone in treatment of PDUB are different, and each has its advantages and disadvantages in the curative effects.