胸腺瘤中P53蛋白表达研究

Expression of P53 Protein in Thymomas

目的:研究P53蛋白在胸腺瘤中的表现及临床意义。方法:用免疫组化染色法观察54例胸腺瘤中P53蛋白表达阳性细胞密度和分布。结果:发现P53表达与胸腺瘤浸润与否密切相关,26例恶性胸腺瘤(Ⅰ和Ⅱ型)中18例P53蛋白高度表达,而28例非浸润性胸腺瘤仅2例高度表达(P＜0.01),P53高度表达患者生存期较非高度表达者明显短。显示P53蛋白表达异常可作为胸腺瘤病变性质和判断病人预后的指标。54例胸腺瘤中49例P53蛋白表达阳性(90.7%)。结论:P53表达异常发生于胸腺瘤的早期。

Aim: To study the expression of P53 in thymomas and its clinical values. Methods: The expression of P53 protein in 54 thymomas was examined immunohistochemically. Results: The expression of P53 correlated to the invasion of thymomas, 18 cases of 26 malignant thymomas were high expressors (the P53-positive tumor cells>50%), whereas only 2 cases of 28 noninvasive thymomas were high expressors. The survival rate was significantly higher for patients with P53 non-high expression than for those with P53 high expression. Conclusion: The expression of P33 protein was a good indicator for the prognosis of thymomas. The high rate of P53 expressions in thymomas (90. 7%)suggested that P53 may be implicated in initial stages of tumorigenesis.