复方甘草酸苷对氯丙嗪所致药物性肝损害疗效观察

目的:探讨复方甘草酸苷在氯丙嗪抗精神病治疗患者发生药物性肝损害中的疗效。方法:123例服用氯丙嗪抗精神病治疗的患者分为治疗组和对照组。治疗组61例,在氯丙嗪抗精神病治疗的基础上加用复方甘草酸昔胶囊3粒/次,3次/日;对照组在氯丙嗪抗精神病治疗的的基础上加用肌苷片每次0.4g,3次/日。对两组治疗药物性肝损害的情况进行比较。结果:两组治疗后肝功能指标均有明显改善,治疗组疗效优于对照组,不良反应轻。结论:复方甘草酸苷可显著降低药物性肝损害的发生。

Objective：To explore the efficacy of compound glycyrrhizin on preventing the hepatic lesion of psychotics treated with chlorpromazine. Methods ： 123 psychotics treated with ehlorpromazine are divided into two groups. Treatment group （ n = 61 ） took compound glyeyrrhizin （3 capsules per time, three times a day） while contrast group （n =62） took inosine tabletes （0.4g per time, three times a day）. Then the hepatic lesion of two groups were compared. Result ：The liver function of both groups improved after treatment. But treatment group was better than contrast group and with fewer adverse reactions. Conclusion： Compound glyeyrrhizin can reduce remarkably the incidence of the hepatic lesion of drugs.