口腔粘膜下纤维性变上皮内微量元素变化及其意义

Changes in trace elements in epithelial cells of oral submucous fibrosis

通过检测口腔粘膜下纤维性变(OSF) 及正常颊粘膜上皮内微量元素含量,了解微量元素与OSF上皮病变的关系,初步探讨OSF的发病机制。应用电子探针显微分析技术,通过电子计算机自动处理,半定量分析OSF上皮细胞核内外微量元素含量变化。结果示,与正常颊粘膜组比较,OSF 组上皮细胞核内外Cu,Zn ,S及As 的含量明显降低,其Se 和Mo 的含量明显升高( 均P < 0 .01) 。提示细胞内低Cu ,Zn 以及高Se 含量加重了对OSF 上皮细胞的损害。

Objectives: To assay the concentrations of the trace elements in intranuclei and extranuclei between oral submucous fibrosis (OSF) and normal buccal membrane, to observe the relationship between the trace elements and OSF, and finally to understand the mechanism of OSF. Methods: The concentrations of the trace elements of internuclei and extranuclei in OSF epithelial cells were assayed in computer automatic process by electron probe micro analysis. Results: The concentrations of Cu, Zn, S, and As in OSF were significantly lower than those in the normal buccal membrane (P<0.01). The concentrations of Se and Mo were significantly higher than those in the normal buccal membrane(P<0.01). Conclusion: The epithelial cells of OSF are seriously damaged by the low level of Cu and Zn and high level of Se in intracell. These changes are the element bases that OSF has canceration trend.$$$$