粒细胞集落刺激因子在急性髓细胞白血病化疗中的作用

EFFECTS OF G CSF ON CHEMOTHERAPY IN ACUTE MYELOID LEUKEMIA

①目的 探讨粒细胞集落刺激因子（Ｇ－ＣＳＦ）在急性髓细胞白血病（ＡＭＬ）化疗中对骨髓造血细胞的作用。②方法 随机选择ＡＭＬ化疗病人５１ 例，其中化疗后应用Ｇ－ＣＳＦ治疗的２７ 例为治疗组，未应用Ｇ－ＣＳＦ治疗的２４ 例为对照组，动态观察骨髓抑制期和恢复期的血细胞变化。③结果 治疗组骨髓抑制期短于对照组，差异有显著意义（ｔ＝ ２．３２，Ｐ＜ ０．０５）。两组缓解率和复发率比较，差异无显著意义（χ２＝ ２．０１０，２．０３１，Ｐ＞ ０．０５）。④结论Ｇ－ＣＳＦ对化疗后骨髓的恢复作用明显。

Objective\ To observe the effects of G CSF on bone marrow cells during chemotherapy in acute myeloid leukemia.\ Methods\ 51 cases of acute myeloid leukemia having chemotherapy were selected for the study, of which 27 cases were treated with G CSF after chemotherapy and 24 cases served as controls, the changes of blood cells during suppression and remission phases of bone marrow were observed.\ Results\ Bone marrow suppression time of treatment group was significantly shorter than that of the control group( t=2.32,P <0.05). There was no significant difference in complete remission rate and recurrence rate between the two groups( χ 2=2.010,2.031,P >0.05).\ Conclusion\ G CSF had obvious effects on bone marrow remission after chemotherapy.\;