复方口服避孕药治疗经前期综合征的临床疗效和安全性评价

Clinical efficacy and safety evaluation of combination oral contraceptive pill for premenstrual syndrome

目的:研究复方口服避孕药物治疗经前期综合征的疗效和安全性。方法:经前期综合征患者86例,随机分为治疗组(45例)和对照组(41例),治疗组给予复方口服避孕药,对照组给予维生素B6。分别用经期不适问卷(MDQ)和证候评分评估服药前和服药1、3、6个周期后经期不适的程度。结果:试验结束后,治疗组的MDQ评分、证候评分较对照组有显著性差异(P<0.05);治疗组和对照组的临床疗效总有效率分别81.1%和48.7%,有明显显著性差异(P<0.01);结论:复方口服避孕药对经前期综合征有较好的疗效和安全性。

Objective：To evaluate the effects of combination oral contraceptive（COC） pill on premenstrual symptoms（PMS） in women.Methods：86 participants with PMS were assigned to experimental group（n=45） and control group（n=41）.The experimental group received oral contraceptive pill,the control group Vitamin B6.Pre-intervention and post-intervention data at 1 menstrual cycle,3 and 6 menstrual cycles were gathered on the biopsychosocial outcomes of PMS.Outcomes were measured through Traditional Chinese Medicine Syndrome scores and Menstrual Distress Questionnaire（MDQ）.Results：Comparing with control group,there was a significant changes in Traditional Chinese Medicine Syndrome scores and MDQ after intervention（P0.05）;Experimental group and control group clinical total effective rate of 81.1% and 48.7%,there was significant difference（P0.01）.Conclusion：Oral contraceptive pill is a safe,readily available,and simple treatment for PMS.