广州4个社区人群中血清乙型肝炎病毒标志物与尿蛋白的相关性分析

Epidemiologic Study on the Relations Between HBV Infection and Proteinuria in Guangzhou Urban Area

目的:探讨广州市部分社区人群中血清乙型肝炎病毒标志物与尿蛋白的相关性。方法:对中山大学孙逸仙纪念医院体检中心6816例社区人群的体检资料进行回顾性分析。结果:6816例个体中,903例(13.25%)HBV携带者,390例(5.72%)尿蛋白阳性。比较HBV携带者[57例/903例(6.31%)]和非HBV携带者[333例/5913例(5.63%)]之间尿蛋白的阳性率,差异无统计学意义(P>0.05)。进一步比较携带者中病毒复制不活跃者(仅HBsAg+)与病毒复制相对活跃者(HBeAg+)之间的尿蛋白阳性率,差异无统计学意义(P>0.05)。结论:HBV携带状态与人群中尿蛋白阳性率无相关性。

Objective：To investigate the prevalence and relationship between chronic HBV infection and proteinuria in four community inhabitants of Guangzhou.Methods：6 816 community people were the subjects of the study.All subjects were assessed HBV status by testing for HBV antigens and antibodies.Proteinuria was assessed by measuring the urinary protein.Results：903（13.25%）of the 6816 subjects were HBV carriers and 390（5.72%） had abnormal proteinuria.The frequency of abnormal proteinuria was not significantly different in those with[57 of 903cases（6.31%）] or without[333 of 5 913cases（5.63%）] HBV carriage（P0.05）.This lack of association remained when carriers were classified into those who were HBsAg positive and those with active viral replication（HBeAg positive）（P0.05）.Conclusion：These results suggest that the HBV infection statuses were not associated with proteinuria.