摘要
目的探讨内镜超声引导下细针穿刺活检(endoscopic ultrasonography guided fine needle aspiration,EUS-FNA)联合囊性纤维化转膜传导调节因子(cystic fibrosis transmembrane conductance regulator,CFTR)基因检测对慢性胰腺炎的诊断价值。方法对本院及哈尔滨医科大学附属第四医院120例慢性胰腺炎患者进行超声内镜引导下穿刺活检,并采用免疫印迹方法检测CFTR基因表达情况。结果活检物中的CFTR检测阳性率明显高于血清中的浓度,其中小胰腺癌检出率为20%。结论 EUS-FNA联合CFTR基因检测对慢性胰腺炎的诊断具有重要价值。
Objective To evaluate significance of diagnosis with endoscopic ultrasonography guided fine needle aspiration(EUS-FNA) accompanied by cystic fibrosis transmembrane conductance regulator(CFTR) detection in chronic pancreatitis.Methods Endoscopic ultrasonography guided fine needle aspiration was performed in 120 patients with chronic pancreatitis at our hospital and the Fourth Affiliated Hospital of Harbin Medical University from August 2003 to December 2005.At the same time CFTR was detected.Results In EUS-FNA specimens of patients,the contents of CFTR were significantly higher than that in blood(P0.05),20% of the patients were dignosed as pancreatic cancer.Conclusion EUS-FNA accompanied by CFTR detection is important in diagnosis of chronic pancreatitis.
出处
《哈尔滨医科大学学报》
CAS
北大核心
2011年第3期266-268,271,共4页
Journal of Harbin Medical University
基金
黑龙江省科技厅资助课题(GC03C605-4)
关键词
内镜超声检查
细针穿刺活检
慢性胰腺炎
囊性纤维化转膜传导调节因子
endoscopic ultrasonography
fine needle aspiration
chronic pancreatitis
cystic fibrosis transmembrane conductance regulator