内镜超声引导下穿刺联合CFTR基因检测对慢性胰腺炎的诊断价值

Diagnostic value of guided fine needle aspiration accompanied by CFTR detection in chronic pancreatitis

目的探讨内镜超声引导下细针穿刺活检(endoscopic ultrasonography guided fine needle aspiration,EUS-FNA)联合囊性纤维化转膜传导调节因子(cystic fibrosis transmembrane conductance regulator,CFTR)基因检测对慢性胰腺炎的诊断价值。方法对本院及哈尔滨医科大学附属第四医院120例慢性胰腺炎患者进行超声内镜引导下穿刺活检,并采用免疫印迹方法检测CFTR基因表达情况。结果活检物中的CFTR检测阳性率明显高于血清中的浓度,其中小胰腺癌检出率为20%。结论 EUS-FNA联合CFTR基因检测对慢性胰腺炎的诊断具有重要价值。

Objective To evaluate significance of diagnosis with endoscopic ultrasonography guided fine needle aspiration（EUS-FNA） accompanied by cystic fibrosis transmembrane conductance regulator（CFTR） detection in chronic pancreatitis.Methods Endoscopic ultrasonography guided fine needle aspiration was performed in 120 patients with chronic pancreatitis at our hospital and the Fourth Affiliated Hospital of Harbin Medical University from August 2003 to December 2005.At the same time CFTR was detected.Results In EUS-FNA specimens of patients,the contents of CFTR were significantly higher than that in blood（P0.05）,20% of the patients were dignosed as pancreatic cancer.Conclusion EUS-FNA accompanied by CFTR detection is important in diagnosis of chronic pancreatitis.