感染HIV-1儿童经抗病毒治疗后乳酸浓度检测及其相关因素研究

Detection of plasma lactic acid in HIV-1 infected children treated with anti-viral therapy and analysis of relevant factors

目的研究中国感染艾滋病毒(human immunodeficiency virus type 1,HIV-1)儿童经抗病毒治疗后血浆乳酸浓度及相关影响因素。方法选择31例抗病毒治疗的感染HIV-1儿童与30例正常对照儿童,检测血浆乳酸浓度,结合儿童的基本信息、治疗方案及实验室检测结果进行综合分析。结果感染HIV-1患儿血浆乳酸浓度(2.32±0.60)mmol/L显著高于对照组儿童(1.60±0.88)mmol/L(P<0.01);d4T治疗组和AZT治疗组间血浆乳酸浓度、基线CD4+T淋巴细胞计数、基线病毒载量、性别、年龄以及HIV-1传播途径差异均无统计学意义(P>0.05)。结论外周血乳酸浓度可反映感染HIV-1儿童经抗病毒治疗后的线粒体毒性,有望成为线粒体毒性检测指标。

Objective To investigate the detection of plasma lactic acid in HIV infected children treated with anti-viral therapy and analyze its related influencing factors.Methods Thirty-one HIV infected children who were treated with anti-retrovirus therapy and 30 control children were chosen to detect their plasma lactic acid levels.The children＇s basic information,therapeutic schedule and laboratory test results were all taken into account in analysis of the relationship with plasma lactic acid.Results Plasma lactic acid of HIV infected children（2.32±0.60 mmol/L） were higher than control children（1.60±0.88 mmol/L）（P0.01）.There were no significant differences in plasma lactic acid levels between d4T group and AZT group.No significant differences were found in baseline CD4＋T cell numbers,baseline viral load,sex,age and route of HIV transmission（P0.05） between the two groups.No statistically significant differences were found among the groups（P0.05）.Conclusion Peripheral blood lactic acid could reflect the mitochondrial toxicity of children receiving anti-retrovirus therapy and may become a new marker of mitochondrial toxicity testing.